Related Experiment Video
Updated: Sep 20, 2025
Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Exploring IL-17 and IL-23 as biomarkers in H. pylori-linked gastric diseases: A cross-sectional study
Refif Sabih Al-Shawk1, Wasan Abdul Elah Bakir1, Zahraa A Mohammed1
1Department of Microbiology, College of Medicine, Mustansiriyah University, Iraq, Baghdad.
Background:
Helicobacter pylori (H. pylori) infection is associated with various gastric diseases, including gastric ulcer (GU) and gastric cancer (GC).
Objective:
The research examines the levels of IL-17 and IL-23 in patients with H. pylori-induced gastric diseases and evaluates the correlation between these cytokines.
Subjects And Methods:
This cross-sectional study was conducted from September 2020 to August 2022. A total of 96 patients were recruited and diagnosed with H. pylori. They were grouped into 56 with GU and 40 with GC. A health control (HC) group of 30 individuals without H. pylori was included. Serum levels of IL-17 and IL-23 were measured in all participants.
Results:
H. pylori-positive patients showed significantly higher IL-17 and IL-23 levels in GU and GC compared to negative groups (P < 0.001). Post-hoc analysis showed the highest level of both cytokines IL-17 and IL-23 difference between H. pylori-positive GC and control (-48.14, p < 0.001 and -36.75, p < 0.001, respectively). There was a positive correlation between IL-17 and IL-23 in both H. pylori-positive (r = 0.573, P < 0.05) and H. pylori-negative (r = 0.452, P < 0.05). High levels of IL-23 were found to increase the risk of GC significantly.
Conclusion:
The serum levels of IL-17 and IL-23 are significantly elevated in patients with GU and GC, regardless of H. pylori status, compared to healthy controls. This suggests their potential role as biomarkers for inflammation and disease progression in gastric conditions associated with H. pylori.
More Related Videos
05:13Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology
Published on: June 13, 2025
03:47Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
Related Concept Videos
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
01:30Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...