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Updated: Sep 20, 2025

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Pre-clinical Model of Cardiac Donation after Circulatory Death
Published on: August 2, 2019
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Ensuring access to novel donor heart preservation modalities
Joseph B Lerman1, Katherine D Marapese2, Amber R Johnson2
1Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC.
Summary
Heart transplantation is rising due to new preservation methods like ex-vivo perfusion, but costs are increasing. This overview examines rising heart donation expenses and proposes solutions for cost savings and improved access.
Area of Science:
- Cardiovascular Surgery
- Transplantation Medicine
- Health Economics
Background:
- Growing demand for heart transplants in the US, despite advances in earlier stage heart disease management.
- Increased utilization of donor hearts through novel procurement and preservation techniques, including ex-vivo heart perfusion.
- Expanded donor pool includes donation after circulatory death (DCD), extended criteria donors, and geographically distant donors.
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