Association between the SUA/Scr ratio and carotid plaque in patients with ischemic stroke based on gender and age: a retrospective study
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View abstract on PubMed
Summary
This summary is machine-generated.The serum uric acid/serum creatinine (SUA/Scr) ratio is linked to carotid plaques (CAPs) in ischemic stroke patients. This association is particularly notable in young and middle-aged men.
Area Of Science
- Neurology
- Nephrology
- Cardiovascular Medicine
Background
- Ischemic stroke is a leading cause of disability and mortality worldwide.
- Carotid plaques (CAPs) are a significant risk factor for ischemic stroke.
- Biomarkers that can predict the presence of CAPs are crucial for stroke prevention strategies.
Purpose Of The Study
- To investigate the association between the serum uric acid/serum creatinine (SUA/Scr) ratio and the presence of carotid plaques (CAPs) in patients who have experienced an ischemic stroke.
- To determine if the SUA/Scr ratio can serve as a predictive marker for CAPs in this patient population.
Main Methods
- A cohort of 12,072 ischemic stroke patients was analyzed.
- Patients were stratified into three groups based on SUA/Scr tertiles.
- Logistic regression and ROC curve analysis were employed to assess the association and predictive value of the SUA/Scr ratio for CAPs.
Main Results
- A significant association was found between the SUA/Scr ratio and CAPs (OR: 1.060; 95% CI: 1.024-1.098).
- Patients in the highest SUA/Scr tertile (Q3) had a higher likelihood of developing CAPs compared to the lowest tertile (Q1) (OR: 1.175; 95% CI: 1.043-1.324).
- This association was prominent in young and middle-aged men (<60 years) but not observed in women or older patients (≥60 years).
Conclusions
- The SUA/Scr ratio is significantly associated with the presence of carotid plaques in ischemic stroke patients.
- The SUA/Scr ratio may serve as a potential biomarker for identifying patients at higher risk of CAPs, particularly among younger and middle-aged men.
- Further research is warranted to elucidate the underlying mechanisms and clinical implications of this association.
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