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Related Experiment Video

Updated: Jun 13, 2025

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Microneedle Arrays for Near-Infrared-Controlled Insulin Delivery Based on Thermosensitive Microgel.

Yinqi Dai¹, Zhenxia Ma¹, Zhuo Shi¹

¹School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

ACS Applied Materials & Interfaces

|May 29, 2025

Summary

This study introduces novel microneedle patches for painless insulin delivery. These patches utilize near-infrared light for controlled, efficient, and on-demand insulin release, improving blood glucose management.

Keywords:

diabetic treatment insulin microneedle patch near-infrared light on-demand drug delivery phase-transition microgel thermosensitive

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Last Updated: Jun 13, 2025

Polymeric Microneedle Array Fabrication by Photolithography

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Published on: November 17, 2015

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Published on: June 1, 2012

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

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Published on: February 13, 2016

Area of Science:

Biomaterials Science
Nanotechnology
Endocrinology

Background:

Current insulin delivery methods face challenges with bioavailability and efficiency.
Painless and minimally invasive insulin administration is crucial for diabetic treatment.

Purpose of the Study:

To develop a novel drug delivery system for controlled, painless, and minimally invasive insulin delivery.
To investigate the efficacy of near-infrared (NIR) light-triggered insulin release using microneedle array patches.

Main Methods:

Fabrication of dissolving microneedle array patches incorporating a thermosensitive microgel (P(NIPAm-AAm)) and MXene nanoparticles.
Utilizing drug-protected protocols to maintain insulin bioactivity during fabrication.
Employing NIR light exposure to trigger rapid heating and insulin release from the microneedles.

Main Results:

The developed microneedles (Ins-MG/MXene-HA-MNs) demonstrated biocompatibility and efficiency in both in vitro and in vivo studies.
NIR light exposure induced rapid heating (above 42 °C in 10 s) and triggered instant insulin release.
A single microneedle patch with two NIR exposures maintained normoglycemia in rats for over 6 hours.

Conclusions:

The MXene-enhanced microneedle array patch enables NIR-controlled, on-demand insulin dosing.
This system shows significant potential for routine blood glucose management in diabetes treatment.
The drug delivery system effectively protects insulin bioactivity, ensuring therapeutic efficacy.