Related Experiment Video

Updated: Sep 20, 2025

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

6.3K

Biological functions and molecular mechanisms of circHIPK3 in digestive system tumors

Jian Li1,2, Xin Su1,2, Xiao Xu1,2

  • 1Department of General Surgery, The First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, No. 204 Donggang West Road, Chengguan District, Lanzhou, 730000, China.

Human Cell
|May 29, 2025
PubMed

Insights

Circular homeodomain-interacting protein kinase 3 (circHIPK3) shows promise as a biomarker and therapeutic target for digestive system tumors. This review highlights circHIPK3's role in cancer progression and its potential for personalized treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Digestive system tumors represent a significant global health burden with high mortality.
  • Circular RNAs (circRNAs) are emerging as critical regulators in various cancers.
  • Circular homeodomain-interacting protein kinase 3 (circHIPK3) is a notable circRNA in cancer research.

Purpose of the Study:

  • To systematically review the clinical potential of circHIPK3 as a biomarker in digestive system tumors.
  • To explore the molecular mechanisms underlying circHIPK3's regulation of cancer-related biological functions.
  • To assess circHIPK3's significance in pharmacotherapy and as a therapeutic target.

Main Methods:

  • Systematic literature review of studies on circHIPK3 in digestive system tumors.
  • Analysis of circHIPK3's role in cell proliferation, survival, migration, invasion, epithelial-mesenchymal transition, metabolism, and angiogenesis.
  • Investigation of circHIPK3's influence on key signaling pathways.

Main Results:

  • circHIPK3 is implicated in regulating multiple hallmarks of cancer progression in digestive system tumors.
  • circHIPK3 influences critical signaling pathways relevant to cancer development and treatment.
  • Evidence suggests circHIPK3's potential as a diagnostic biomarker and therapeutic target.

Conclusions:

  • circHIPK3 holds significant promise as a clinical biomarker for digestive system tumors.
  • Understanding circHIPK3's molecular functions can guide the development of novel therapeutic strategies.
  • Further research into circHIPK3 may lead to individualized treatment protocols for digestive cancers.
Keywords:
BiomarkerCircHIPK3Digestive system tumorMolecular mechanismTherapeutic target

More Related Videos

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

6.5K
Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

2.2K

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.6K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
4.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K