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Updated: Jun 14, 2025

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
Lewis Acid-Mediated Deoxygenative Synthesis of Trivalent Sterically Hindered Phosphines from Aldehydes
Xiaoqiang Wu1, Abuduwaili Alimu1, Wei Zhong2
1Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. China.
Abstract:
The efficient synthesis of trisubstituted trivalent phosphines remains challenging. Herein, we report a novel approach for rapid construction of these compounds from aldehydes under Lewis acid-mediated conditions. By using sterically hindered disubstituted phosphines, aldehydes can undergo a deoxygenative reaction to afford trivalent phosphorus compounds. This modular and practical method is characterized by operational simplicity, a broad substrate scope, and excellent functional group tolerance, which holds great potential for applications in organic synthesis.
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