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Positive Correlation between Lipin-1 and Lipin-2 Expressions and Hepatic T1 Values in IUGR Rats.

Tao Wang1, MingZhu Deng1, Alpha Kalonda Mutamba1

  • 1Department of Pediatric, Second Xiangya Hospital of Central South University, Changsha, China.

Current Medical Imaging
|May 30, 2025
PubMed
Summary

Intrauterine growth restriction (IUGR) in rats leads to increased lipin-1 and lipin-2 expression, correlating with higher liver T1 values and potentially contributing to adult obesity.

Keywords:
Hepatic T1 valuesIntrauterine growth restrictionLipin-1Lipin-2.T1 mapping

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Area of Science:

  • Metabolic research
  • Molecular biology
  • Medical imaging

Background:

  • Intrauterine growth restriction (IUGR) is linked to long-term metabolic issues like obesity.
  • Lipin-1 and lipin-2 mediate hepatic lipid metabolism and adipose tissue function, potentially contributing to IUGR-related obesity.

Purpose of the Study:

  • Investigate the relationship between lipin-1 in visceral adipose tissues (VATs) and lipin-2 in the liver.
  • Examine hepatic T1 values using T1 mapping in IUGR rats.
  • Explore metabolic mechanisms connecting IUGR and adult obesity using molecular and imaging markers.

Main Methods:

  • Induced IUGR in rats using a low-protein diet (10%) versus a control diet (21%).
  • Assessed male offspring at days 21, 56, and 84 post-birth using MRI and native T1 mapping.
  • Measured lipin-1 and lipin-2 expression (mRNA and protein) in liver and VATs via Western blot and qPCR.

Main Results:

  • IUGR rats showed significantly higher lipin-1 and lipin-2 mRNA and protein levels compared to controls at all time points.
  • IUGR rats exhibited significantly elevated hepatic T1 values at all measured time points.
  • Positive correlations were found between lipin-1/lipin-2 expression and hepatic T1 values (P<0.05).

Conclusions:

  • Upregulated lipin-1 and lipin-2 expression in IUGR rats is associated with elevated hepatic T1 values.
  • These molecular and imaging changes may contribute to the development of adult obesity in IUGR offspring.