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Early-Life Microbiome and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis

Md Fakruddin1, Tasbir Amin1, Md Asaduzzaman Shishir2

  • 1Department of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.

Current Neuropharmacology
|May 30, 2025
PubMed

Insights

Gut microbiota imbalances are linked to neurodevelopmental disorders like Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) in early childhood. Further research is needed to confirm these findings.

Area of Science:

  • Microbiome research
  • Neurodevelopmental disorders
  • Pediatric health

Background:

  • Early childhood gut microbiota composition is increasingly recognized as a factor influencing neurodevelopment.
  • Microbial dysbiosis has been hypothesized to play a role in the etiology of neurodevelopmental conditions.
  • Understanding these gut-brain axis connections is crucial for identifying potential early interventions.

Conclusions:

  • Gut microbiome alterations in early life may contribute to the development of ASD and ADHD.
  • Microbial imbalances represent a potential factor in neurodevelopmental disorders.
  • Larger, high-quality longitudinal studies are essential to strengthen evidence and improve data quality.
Abstract

Keywords:
Attention Deficit Hyperactivity Disorder (ADHD)Autism Spectrum Disorder (ASD)Early-life microbiomegut-brain axisneurodevelopmental disorderssystematic review.

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