Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spanning Openings in Brick Walls01:20

Spanning Openings in Brick Walls

266
In brick wall construction, supporting structures are crucial for openings like windows and doors to maintain the integrity and support the weight of the wall above. These supports include lintels, corbels, and arches, each serving specific structural purposes.
Lintels are primary supports used to span openings and can be crafted from materials such as reinforced concrete, steel-reinforced brick masonry, or simple steel angles. These are straightforward to install and are typically concealed...
266
Seedless Vascular Plants03:24

Seedless Vascular Plants

61.5K
Seedless Vascular Plants Were the First Tall Plants on Earth
61.5K
Brick Cutting Techniques01:08

Brick Cutting Techniques

242
Brick-cutting techniques involve various tools and methods to shape bricks for construction. A mason's hammer with a chisel-pointed end is used for basic shaping through sharp, precise strikes. For more complex shapes requiring higher precision, a power saw with a water-cooled diamond blade is used.
Cut bricks are categorized by size. Bricks cut to half their original length are called half-bats, while those cut to three-fourths their length are known as three-fourth bats.
Special types of...
242
Development of Blood Vessels01:07

Development of Blood Vessels

816
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
816
Anatomy of Blood Vessels01:20

Anatomy of Blood Vessels

1.0K
The vascular system, an integral part of the circulatory system, comprises various blood vessels that play crucial roles in maintaining the body's homeostasis. These blood vessels form a complex and efficient circulatory network. The three primary categories of blood vessels are the arteries, veins, and capillaries.
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta,...
1.0K
Types of Building Separation Joints01:23

Types of Building Separation Joints

335
Building separation joints divide large or complex building structures into smaller, discrete units that can move independently. These joints are categorized into three types: volume-change joints, settlement joints, and seismic separation joints.
Volume-change joints address the effects of expansion and contraction due to temperature and moisture variations. They are strategically placed at discontinuities in a building's mass where cracking is most likely and are spaced about 150 to 200...
335

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diffusion Model-Based Design of Bionic Bone Scaffolds with Tunable Microstructures.

Annals of biomedical engineering·2025
Same author

A Low-Cost High-Performance Data Augmentation for Deep Learning-Based Skin Lesion Classification.

BME frontiers·2023
Same author

Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species.

Molecular nutrition & food research·2016
Same author

Soyasaponins prevent H₂O₂-induced inhibition of gap junctional intercellular communication by scavenging reactive oxygen species in rat liver cells.

Nutrition and cancer·2014
Same author

Soyasaponins can blunt inflammation by inhibiting the reactive oxygen species-mediated activation of PI3K/Akt/NF-kB pathway.

PloS one·2014
Same author

Evaluating the impact of environmental temperature on global highly pathogenic avian influenza (HPAI) H5N1 outbreaks in domestic poultry.

International journal of environmental research and public health·2014
Same journal

Rational Design of LiNi<sub>1-x</sub>Fe<sub>x</sub>O<sub>2</sub> Electrodes for Enhanced Oxygen Evolution Reaction Under Power-Fluctuating Operations in Alkaline Water Electrolysis.

Small methods·2026
Same journal

One-Step Electrosynthesis of Polyoxometalate-Based Organic-Inorganic Hybrid Polymers and Their Confinement in Vertically Oriented Mesoporous Silica.

Small methods·2026
Same journal

Bioinspired Superlight Carbon Nanotube Aerogel With Exceptionally High Kinetic Energy Absorption up to 385.47 MJ/m<sup>3</sup>.

Small methods·2026
Same journal

Aptamer Circuit-Engineered Bio-Nanovesicles With Self-Promoted Tumor-Targeting Loop for Efficient Immunogenic Chemotherapy.

Small methods·2026
Same journal

Boosting High Thermoelectric Performance of n-type AgBiSe<sub>2</sub> via Rapid Synthesis Strategy.

Small methods·2026
Same journal

Synergistic Integration of Intermediate Adsorption and Hydrogen Supply to Boost Nitrate Electroreduction to Ammonia Performance via Anchoring Nickel on Monolithic Copper Nanocone Arrays.

Small methods·2026
See all related articles

Related Experiment Video

Updated: Sep 20, 2025

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

3.6K

Lego-Inspired Splicing of Modularized Vascular Channels.

Xiaoyan Zou1,2,3, Shilu Zhu1,3, Yifeng Xia2

  • 1School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.

Small Methods
|May 30, 2025
PubMed
Summary
This summary is machine-generated.

A novel modular splicing technique enables scalable construction of perfusable vascular channels in tissue-engineered hydrogels. This Lego-inspired method allows flexible assembly for advanced in vitro vascularized tissue development.

Keywords:
hierarchical networklarge‐scalemodularizationsplicingvascular channels

More Related Videos

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks
10:53

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Published on: January 3, 2017

10.0K
4D Printed Bifurcated Stents with Kirigami-Inspired Structures
06:52

4D Printed Bifurcated Stents with Kirigami-Inspired Structures

Published on: July 25, 2019

8.1K

Related Experiment Videos

Last Updated: Sep 20, 2025

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

3.6K
Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks
10:53

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Published on: January 3, 2017

10.0K
4D Printed Bifurcated Stents with Kirigami-Inspired Structures
06:52

4D Printed Bifurcated Stents with Kirigami-Inspired Structures

Published on: July 25, 2019

8.1K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Vascular channels in tissue-engineered hydrogels are vital for nutrient transport and waste removal, mimicking physiological conditions.
  • Current methods for creating vascular channels in hydrogels face challenges in flexibility and scalability.
  • Developing methods for constructing hierarchical vascular networks is crucial for advanced tissue engineering applications.

Purpose of the Study:

  • To introduce an innovative modular construction strategy for developing perfusable vascular channels within hydrogels.
  • To demonstrate the flexibility and scalability of this splicing technique for creating large-scale vascularized hydrogel constructs.
  • To validate the functionality and barrier properties of the engineered vascular channels.

Main Methods:

  • A Lego-inspired modular assembly approach was employed to design and fabricate hydrogel modules with diverse vascular channel architectures.
  • Customized modules were spliced together to create large-scale constructs with hierarchical vascular channels in 1D, 2D, and 3D.
  • Gelatin-based hydrogels were used, and the constructs were perfused to assess flow and interfacial strength.
  • A functionalized construct mimicking vascular barrier function using human umbilical vein endothelial cells (HUVECs) was established and tested under flow.

Main Results:

  • The modular splicing technique successfully created flexible and scalable vascular hydrogel constructs.
  • The engineered vascular channels were demonstrated to be perfusable, with characterized interfacial strengths.
  • The functionalized construct successfully mimicked vascular barrier function, maintaining endothelial cell integrity and functionality under flow.
  • The technique proved effective across 1D, 2D, and 3D configurations.

Conclusions:

  • The innovative splicing technique provides a versatile platform for constructing large-scale, in vitro vascularized tissues.
  • This method addresses the limitations of current techniques in achieving flexible and scalable vascular channel fabrication.
  • The findings offer new insights and potential solutions for specific tissue engineering needs, advancing the field of regenerative medicine.