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Updated: Mar 10, 2026

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Reproductive function and sperm parameters in men with sickle cell disease: a systematic review.

Clarisse Leblanc1, Nathalie Sermondade1,2, Ludmilla Ogouma-Aworet1

  • 1Reproductive Biology Department, CECOS, Tenon Hospital, AP-HP. Sorbonne University, Paris 75020, France.

Asian Journal of Andrology
|May 30, 2025
PubMed
Summary

Sickle cell disease (SCD) impairs male fertility, with treatments like hydroxyurea (HU) and hematopoietic stem cell transplantation (HSCT) posing further risks. Early fertility counseling and preservation are crucial for affected males.

Keywords:
fertility preservationhydroxyureamale reproductive functionssickle cell diseasesperm parameters

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