Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.3K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Cancer Therapies02:49

Cancer Therapies

8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.0K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.0K
What is Cancer?02:12

What is Cancer?

11.2K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
11.2K
Cancer02:18

Cancer

49.9K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
49.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Epidemiological characteristics and analysis of related infection risk factors for influenza in Anhui Province from 2013 to 2021].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2023
Same author

Agrobacterium-mediated transformation of tomato (Solanum lycopersicum L.) using the expansin 10 (CsEXP10) gene.

Genetics and molecular research : GMR·2015
Same journal

[shRNA-mediated downregulation of TERT inhibits melanoma in vitro and in vivo].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2026
Same journal

[Exploration on the application of perineal lateral arc-shaped incision in the resection of complex tumors on the lateral side of the pelvic floor].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2026
Same journal

[Risk stratification assessment of brain metastasis in newly diagnosed non-stage IV breast cancer patients with HER-2-low expression following systemic therapy].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2026
Same journal

[Clinicopathological analysis of SMARCA4-deficient tumors of digestive system origin].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2026
Same journal

[cfDNA sequencing reveals response heterogeneity to first-line camrelizumab plus chemotherapy in esophageal squamous cell carcinoma].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2026
Same journal

[Efficacy and safety of combination immunotherapy for locally advanced esophageal carcinoma].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2026
See all related articles

Related Experiment Video

Updated: Sep 20, 2025

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

491

[Rethinking cancer].

W R Luo1

  • 1Department of Pathology, Shenzhen Third People's Hospital, the Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen 518112, China.

Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]
|May 30, 2025
PubMed
Summary
This summary is machine-generated.

Cancer research must evolve beyond the somatic mutation theory. A new "tumor system" and "tumor ecology" framework offers a paradigm shift for effective cancer eradication and treatment strategies.

More Related Videos

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

19.8K
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

12.8K

Related Experiment Videos

Last Updated: Sep 20, 2025

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

491
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

19.8K
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

12.8K

Area of Science:

  • Oncology
  • Systems Biology
  • Ecological Pathology

Background:

  • The dominant "somatic mutation" theory has driven cancer research for 50 years, influencing precision medicine and vaccine development.
  • Despite extensive research into tumor genetics and microenvironment, curative cancer treatments remain elusive.
  • Current reductionist approaches focusing on mutations may hinder significant progress in cancer understanding and treatment.

Purpose of the Study:

  • To advocate for a paradigm shift in cancer research, moving beyond the limitations of the somatic mutation theory.
  • To introduce and elucidate the novel
  • tumor system
  • perspective for understanding cancer's essence.
  • To explore the foundational principles of
  • tumor ecology
  • and
  • ecological pathology
  • for novel treatment applications.

Main Methods:

  • Systematic elucidation of the
  • tumor system
  • concept.
  • Exploration of
  • tumor ecology
  • principles and their therapeutic potential.
  • In-depth analysis of the theoretical framework and research significance of
  • ecological pathology
  • .

Main Results:

  • Identifies the limitations of the current somatic mutation paradigm in achieving cancer cures.
  • Proposes the
  • tumor system
  • as a comprehensive framework for understanding cancer.
  • Highlights
  • tumor ecology
  • and
  • ecological pathology
  • as emerging fields with significant therapeutic implications.

Conclusions:

  • A fundamental re-evaluation and transformation of the conceptual framework in cancer research is imperative.
  • The proposed
  • tumor system
  • and
  • tumor ecology
  • framework offers a pragmatic path forward for the post-genomic era of oncology.
  • Adopting an ecological approach is crucial for achieving the ultimate goal of cancer eradication.