Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Latamoxef: single agent prophylaxis in colorectal surgery.

W E Thomas, M J Cooper, A Holt

    The Journal of Antimicrobial Chemotherapy
    |July 1, 1985
    PubMed
    Summary

    Latamoxef (moxalactam) shows promise as a single-agent prophylactic antibiotic for colorectal surgery. It demonstrated comparable or improved outcomes compared to combination therapy, with fewer infections and complications.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence of canine intestinal parasites and associated fecal bacteria among urban and rural dog parks in central Appalachia U.S.

    Veterinary parasitology, regional studies and reports·2025
    Same author

    Behaviour regulation and the role of mental health in non-alcoholic fatty liver disease.

    BMC gastroenterology·2023
    Same author

    Obesity bias and stigma, attitudes and beliefs among entry-level physiotherapy students in the Republic of Ireland: a cross sectional study.

    Physiotherapy·2021
    Same author

    Identifying ecological production functions for use in ecosystem services-based environmental risk assessment of chemicals.

    The Science of the total environment·2021
    Same author

    Stability of dissolved and soluble Fe(II) in shelf sediment pore waters and release to an oxic water column.

    Biogeochemistry·2020
    Same author

    Structurally Related Scaling Behavior in Ionic Systems.

    The journal of physical chemistry. B·2020

    Area of Science:

    • Infectious Diseases
    • Surgical Prophylaxis
    • Pharmacology

    Background:

    • Antibiotic prophylaxis is crucial in preventing surgical site infections (SSIs) in colorectal surgery.
    • Current standard prophylaxis often involves combination antibiotic regimens.
    • Evaluating single-agent alternatives can simplify treatment and potentially reduce side effects.

    Purpose of the Study:

    • To evaluate the efficacy and safety of latamoxef (moxalactam) as a single-agent chemoprophylaxis in elective colorectal surgery.
    • To compare latamoxef with a standard combination regimen of cephazolin and metronidazole.
    • To assess various infection rates, inpatient stay, and patient outcomes.

    Main Methods:

    • A randomized controlled trial involving 120 patients undergoing elective colorectal surgery.
    • Patients received either latamoxef (1 g) or cephazolin (1 g) plus metronidazole (500 mg) intravenously.
    • Dosing occurred at anesthesia induction and 6 and 12 hours postoperatively.

    Main Results:

    • Latamoxef achieved adequate serum and tissue levels above the minimum inhibitory concentration (MIC90) for common bowel organisms.
    • Fewer patients in the latamoxef group experienced pyrexia, wound infection, major intra-abdominal sepsis, chest infection, and urinary sepsis.
    • Rates of anastomotic leakage, bleeding complications, and inpatient stay were similar between groups.

    Conclusions:

    • Latamoxef is an effective chemoprophylactic agent in elective colorectal surgery.
    • Latamoxef demonstrated a marginally better safety and efficacy profile compared to cephazolin plus metronidazole.
    • Single-agent latamoxef prophylaxis warrants consideration for elective colorectal procedures.

    Related Experiment Videos