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Evaluation of Function and Biochemical Parameters of Platelet Concentrates (PCs) Prepared From Blood Donors With a History of COVID-19 During the Platelet Storage

  • 0Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Journal of Clinical Laboratory Analysis +

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May 30, 2025

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May 30, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Platelet concentrates from donors recently recovered from COVID-19 show impaired function, particularly in response to arachidonic acid. This suggests selective platelet dysfunction post-infection, impacting transfusion safety.

Area Of Science

  • Transfusion Medicine
  • Hematology
  • Immunology

Background

  • COVID-19 can alter hematological and biochemical parameters, affecting platelet function.
  • The long-term impact of COVID-19 on platelet concentrate (PC) quality from recovered donors is not fully understood.

Purpose Of The Study

  • To evaluate the long-term effects of COVID-19 on the quality of platelet concentrates (PCs).
  • To assess platelet function and biochemical parameters in PCs from donors with a history of COVID-19 infection.

Main Methods

  • Twenty PCs were collected from male donors recovered from COVID-19.
  • Donors were categorized into control (recovered >6 months) and case (recovered 1-3 months) groups.
  • Metabolic, oxidative parameters, and platelet aggregation were measured during PC storage.

Main Results

  • Both groups showed expected storage-related changes in glucose, pH, lactate, LDH, and ROS.
  • Collagen-induced platelet aggregation decreased over time similarly in both groups.
  • Arachidonate-induced platelet aggregation significantly decreased over time in the case group compared to controls.

Conclusions

  • PCs from donors recently recovered from COVID-19 exhibit selective impairment in platelet function, notably reduced arachidonate-induced aggregation.
  • Biochemical markers did not significantly differ between groups.
  • Further research with larger cohorts is needed to assess the clinical efficacy and safety of PCs from recovered COVID-19 donors.

Keywords: