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Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Related Experiment Video

Updated: Jul 5, 2026

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Published on: September 28, 2022

There's never been a better time to be a STEM educator.

Jason Williams¹

¹DNA Learning Center, Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.

|May 30, 2025

Summary

US STEM education, despite challenges, shows a bright future due to strong demand for a skilled workforce. Innovative teaching methods and accessible technologies like DNA sequencing are key drivers for success.

Keywords:

STEM education course-based research genomics nanopore sequencing

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Last Updated: Jul 5, 2026

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

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Published on: September 28, 2022

Visualization of Organelles In Situ by Cryo-STEM Tomography

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Published on: February 23, 2024

Area of Science:

STEM Education
Economics
Life Sciences

Background:

Current perceptions of US STEM education are often negative, yet its importance is increasing.
The US is the world's most entrepreneurial nation, creating unique market forces.
Product-market fit, an economic concept, can be applied to assess STEM education's viability.

Purpose of the Study:

To analyze the current state and future outlook of US STEM education.
To frame the optimistic future of STEM education through the lens of product-market fit.
To highlight the role of innovative educational models and technologies.

Main Methods:

Analysis of market forces and strategic interests driving demand for a STEM workforce.
Examination of course-based research and inquiry-based teaching models.
Case study reflection on the Cold Spring Harbor Laboratory DNA Learning Center's (DNALC) approach.

Main Results:

US STEM education has achieved and surpassed product-market fit.
National strategic interests create significant unmet demand for a prepared STEM workforce.
Life sciences, utilizing DNA sequencing, offer a scalable, multidisciplinary educational platform.

Conclusions:

STEM education in the US has a strong and promising future.
Investment and engagement are crucial to meet the nation's STEM workforce needs.
The DNALC model demonstrates a successful approach to STEM education infrastructure and distribution.