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Triglycerides-Total Cholesterol-Body Weight Index, bone metabolism indicators and bone mineral density in Chinese
Xueyi Jin1, Xueqian Mao1, Ying Hu1
1Department of Epidemiology and Statistics, School of Public Health, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu Province, 730000, China.
Insights
The Triglycerides × Total Cholesterol × Body Weight Index (TCBI) positively correlates with bone mineral density (BMD) in preschoolers. Insulin-like growth factor 1 (IGF-1) and bone-specific alkaline phosphatase (B-ALP) partially mediate this association.
Area of Science:
- Pediatric Endocrinology
- Bone Metabolism
- Biomarkers in Child Health
Background:
- Childhood obesity and metabolic health are critical public health concerns.
- Understanding factors influencing bone mineral density (BMD) in early life is essential for long-term skeletal health.
- The Triglycerides × Total Cholesterol × Body Weight Index (TCBI) is a composite index reflecting metabolic status.
Purpose of the Study:
- To investigate the correlation between the TCBI and BMD in preschool children.
- To determine if bone-specific alkaline phosphatase (B-ALP) and insulin-like growth factor 1 (IGF-1) mediate the TCBI-BMD relationship.
Main Methods:
- A cohort of 411 preschool children from rural China was studied over two years.
- TCBI was assessed at baseline and follow-up; BMD was measured using dual-energy X-ray absorptiometry.
- Multiple linear regression and mediation analyses were employed to examine associations.
Main Results:
- A significant positive correlation was found between TCBI and BMD in preschoolers (P < 0.001).
- Each unit increase in log-transformed TCBI was associated with increased BMD in the forearm and heel.
- IGF-1 and B-ALP partially mediated the positive association between TCBI and BMD.
Conclusions:
- The TCBI is positively associated with forearm and heel BMD in preschool children.
- IGF-1 and B-ALP play a partial mediating role in the relationship between TCBI and BMD.
- These findings highlight potential metabolic influences on early bone development.
Purpose:
This study aimed to investigate the correlation between the Triglycerides × Total Cholesterol × Body Weight Index (TCBI) and bone mineral density (BMD) in children and whether bone-specific alkaline phosphatase (B-ALP), and insulin-like growth factor 1 (IGF-1) mediate the relationship between TCBI and BMD.
Methods:
This study included 411 preschool children from 2 township kindergartens in a rural area of Gansu Province, China, who were surveyed at baseline in September 2021 and followed up in September 2022. The independent variable is the mean value of TCBI at baseline and follow-up. The dependent variable was the raw value of BMD during the follow-up period, measured by dual-energy X-ray absorptiometry. Multiple linear regression was used to analyze the relationship between TCBI and BMD in the nondominant forearm and heel bone.
Results:
The results showed that TCBI in preschoolers was significantly and positively correlated with BMD (P < 0.001). In the fully adjusted model, for each unit increase in log-transformed TCBI, the BMD of the nondominant forearm and heel bone increased by 0.042 g/cm2 (95% CI: 0.024, 0.059), and 0.034 g/cm2 (95% CI: 0.015, 0.054), respectively. Mediation analyses showed that IGF-1 mediated TCBI and BMD of the forearm bone and heel bone with mediation proportions of 12.50% and 32.35%, respectively, whereas B-ALP mediated TCBI and BMD of the forearm bone and heel bone with mediation proportions of 10.00% and 11.76%, respectively.
Conclusion:
TCBI is positively correlated with nondominant forearm and heel BMD in preschoolers, and IGF-1 and B-ALP partially mediate the positive association between TCBI and BMD.
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