Protective Effect of FABP5 Against 6-OHDA Induced Parkinson's Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway

Mitochondrial dysfunction of neurons is an important feature of Parkinson's disease (PD). Fatty acid binding protein 5 (FABP5) is a protein that regulates mitochondrial function and protects cell from neuronal injury. However, the potential of FABP5 administration to restore mitochondria has not been fully explored. In this study, PC12 cells and rats were induced by 6-hydroxydopamine (6-OHDA) to establish PD models. Our results showed that FABP5 promoted cell proliferation and protected against mitochondrial damage, and reduced apoptosis in vitro and vivo. Moreover, FABP5 treatment alleviates motor and non-motor symptom injury in vivo. It also effectively modulated the PPARγ/SIRT1/PGC-1α signaling pathway, thereby mitigating 6-OHDA-induced neurotoxicity. These results suggest that FABP5 exerts mitochondrial protection, inhibits apoptosis, restores damaged dopaminergic neurons, and slows down PD.