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Related Experiment Video

Updated: Jun 16, 2025

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Transepithelial Versus Conventional PRK: A Randomized Controlled Study.

Robert Edward T Ang1,2

  • 1Asian Eye Institute, 8th Floor PHINMA Plaza Bldg., Hidalgo Drive, Rockwell Center, 1200, Makati City, Philippines. rtang@asianeyeinstitute.com.

Ophthalmology and Therapy
|May 30, 2025
PubMed
Summary

Transepithelial photorefractive keratectomy (t-PRK) and conventional photorefractive keratectomy (PRK) offer equally safe and effective vision correction for ametropia. The study found no significant differences in outcomes, suggesting t-PRK

Keywords:
Alcohol-assisted photorefractive keratectomyAmetropiaHyperopiaMyopiaRefractive surgeryTransepithelial photorefractive keratectomy

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Area of Science:

  • Ophthalmology
  • Refractive Surgery

Background:

  • Transepithelial photorefractive keratectomy (t-PRK) is an advanced single-step laser procedure for vision correction.
  • It differs from conventional photorefractive keratectomy (PRK), a two-step process involving manual epithelial removal before stromal ablation.

Purpose of the Study:

  • To compare the safety and efficacy of t-PRK versus conventional PRK for correcting ametropia.
  • To evaluate refractive predictability, visual acuity, and patient-reported outcomes.

Main Methods:

  • A prospective, randomized, controlled, contralateral, masked study involving 35 adult subjects.
  • One eye underwent conventional PRK, the other t-PRK, with a 6-month follow-up period.
  • Primary endpoint: absolute refractive predictability at 3 months; secondary endpoints: safety, visual acuity, and patient satisfaction.

Main Results:

  • Both t-PRK and conventional PRK demonstrated non-inferiority in refractive predictability (p=0.2253).
  • No statistically significant differences were observed in manifest refraction or visual acuity between the two procedures at 6 months.
  • All subjects reported satisfaction with both procedures, with no preference for one over the other.

Conclusions:

  • Conventional PRK and t-PRK are equally safe and effective for ametropia correction.
  • The efficiency of t-PRK may be a consideration when PRK is indicated.
  • Both methods yield favorable outcomes for patients seeking vision correction.