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Intersection of Autoimmunity: NMDA Positivity, Hypertrophic Pachymeningitis, and Primary CNS Angiitis in a Single

Ravi P Singh1, S Rima2, Seetam Kumar3

  • 1Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

Annals of Indian Academy of Neurology
|May 30, 2025
PubMed
Abstract

No abstract available in PubMed .

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Encephalitis l: Introduction01:19

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Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
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Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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