Related Experiment Video
Updated: Sep 20, 2025

Skeletal Muscle Gender Dimorphism from Proteomics
Published on: December 14, 2011
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale
Macsue Jacques1, Shanie Landen2, Adam P Sharples3
1Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia; Institute for Health and Sport (iHeS), Victoria University, Footscray, VIC, Australia.
Abstract:
We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO2max), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcription factors functioning as activators, synergizing with DNA methylation to regulate gene expression. Minimal sex differences were observed, while modality-specific analysis highlighted distinct pathways for aerobic and resistance exercise, contrasting with muscle disuse patterns. Finally, we created a webtool, OMAx, featuring our individual omics and integration analysis. These findings provide a comprehensive multi-omics framework for understanding exercise-induced molecular adaptations, offering insights into muscle health, cardiorespiratory fitness, and their roles in aging and disease prevention.
More Related Videos
Related Concept Videos
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Inclusive Fitness
Overview of Skeletal Muscle
Genomics
Skeletal Muscle Anatomy
Classification of Skeletal Muscle Fibers
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...

