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Long-term effect of liver resection in T2 and T3 gallbladder cancer

  • 0Department of Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology +

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May 30, 2025

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May 30, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Radical surgery, including liver resection and lymph node dissection, significantly improves long-term survival for gallbladder cancer patients. Key factors influencing outcomes include tumor stage and specific surgical techniques.

Area Of Science

  • Oncology
  • Surgical Oncology
  • Cancer Research

Background

  • Limited long-term outcome data exists for gallbladder cancer post-AJCC 8th edition.
  • Gallbladder cancer staging and treatment require further investigation for improved survival.

Purpose Of The Study

  • To evaluate the impact of surgical interventions on long-term survival in T2/T3 gallbladder cancer.
  • To identify prognostic factors for overall survival in gallbladder cancer patients.

Main Methods

  • Retrospective analysis of 180 T2/T3 gallbladder cancer patients (2010-2019).
  • Defined radical resection as liver resection with ≥4 lymph nodes procured.
  • Assessed overall survival (OS) based on surgical procedures and prognostic factors.

Main Results

  • Liver resection improved 5-year OS (43.8% vs. 26.7%, p=0.047).
  • Radical resection (liver resection + ≥4 lymph nodes) significantly increased 5-year OS (52.5% vs. 31.7%, p=0.014).
  • T stage, perineural invasion, CA 19-9 levels, and radical resection were independent prognostic factors for OS.

Conclusions

  • Radical surgery, including hepatic resection and lymph node dissection, is crucial for T2-T3 gallbladder cancer.
  • AJCC T stage, perineural invasion, elevated CA 19-9, and radical resection independently predict overall survival.

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