Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

184
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
184
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

303
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
303
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

2.4K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.4K
Regression Toward the Mean01:52

Regression Toward the Mean

6.5K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.5K
Factors Affecting Illness01:18

Factors Affecting Illness

4.5K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.5K
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

397
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
397

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Course and Determinants of Remission in Children and Adolescents with Prediabetes: Authors' Reply.

Indian journal of pediatrics·2026
Same author

MaxI-Net: A 3D AI Framework for CBCT-Based Maxillofacial Defect Reconstruction and Patient-Specific Implant Generation with Biomechanical Validation.

Bioengineering (Basel, Switzerland)·2026
Same author

Pneumococcal meningitis among hospitalised children after introduction of pneumococcal conjugate vaccine in India: a sentinel hospital surveillance (2019-2022).

The Lancet regional health. Southeast Asia·2026
Same author

Clinico-epidemiological profile findings of the screened population under NPCDCS-Ayush (Integration of Homeopathy along with Yoga): a pilot project.

Frontiers in public health·2026
Same author

Development and Validation of Puberty Interpreter, a Mobile Clinical Decision-Support Tool for Pubertal Disorders.

Indian journal of pediatrics·2026
Same author

MASLD as a crucial component in the pathogenesis, evaluation and management of type 2 diabetes in Asian Indians.

Diabetes & metabolic syndrome·2026
Same journal

Response to the Letter to the Editor: A Novel Method for Estimating the Sensitivity of Homeopathic Repertories: A Critical Analysis.

Homeopathy : the journal of the Faculty of Homeopathy·2026
Same journal

A Novel Method for Estimating the Sensitivity of Homeopathic Repertories: A Critical Analysis.

Homeopathy : the journal of the Faculty of Homeopathy·2026
Same journal

Homeopathy for Hemorrhoids: Protocol for a Systematic Review.

Homeopathy : the journal of the Faculty of Homeopathy·2026
Same journal

The Emission of Photons by Arsenicum album 10M Suggests that Potencies are in a High-Energy, Low-Density State.

Homeopathy : the journal of the Faculty of Homeopathy·2026
Same journal

Antidotes in Homeopathy: Classical Doctrine, Clinical Relevance and Scientific Re-interpretation.

Homeopathy : the journal of the Faculty of Homeopathy·2026
Same journal

Material Characterization of Ethanolic Preparation of Natrium muriaticum 4C to 200C.

Homeopathy : the journal of the Faculty of Homeopathy·2026
See all related articles

Related Experiment Video

Updated: Sep 20, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.8K

How to Assess Variation in Homeopathic Prognostic Factor Research?

Lex Rutten1, José E Eizayaga2, Harleen Kaur3

  • 1Independent researcher, Breda, The Netherlands.

Homeopathy : the Journal of the Faculty of Homeopathy
|May 30, 2025
PubMed
Summary
This summary is machine-generated.

Statistical analysis of polar symptoms (PS) in prognostic factor research (PFR) revealed asymmetry. Cumulative binomial probability (CBP) helps classify the reliability of PFR outcomes, aiding clinical decision-making.

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

503
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.8K

Related Experiment Videos

Last Updated: Sep 20, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

15.8K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

503
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.8K

Area of Science:

  • Homeopathy Research
  • Statistical Analysis in Medicine
  • Prognostic Factor Research (PFR)

Background:

  • Prognostic Factor Research (PFR) often involves analyzing polar symptoms (PS), which present with opposite values (e.g., amelioration/desire vs. aggravation/aversion).
  • Observed differences in PS frequency distributions, such as 'Desire salt' vs. 'Aversion salt' for *Arsenicum album*, raise questions about statistical variation.
  • Previous research and current data collection methods may lead to asymmetrical frequency distributions in PS.

Purpose of the Study:

  • To classify the reliability of outcomes from prognostic factor research (PFR), particularly for polar symptoms (PS).
  • To assess the influence of statistical variation on observed differences in PS.
  • To compare the usefulness of Cumulative Binomial Probability (CBP) and 95% Confidence Intervals (95% CIs) for daily practice in PFR.

Main Methods:

  • Analysis of frequency distributions of polar symptoms (PS) and comparison with previous research.
  • Calculation of Cumulative Binomial Probability (CBP) and 95% Confidence Intervals (95% CIs) to assess statistical variation.
  • Calibration of CBP using 95% CIs and validation of outcomes through corroboration by comparable symptoms.

Main Results:

  • Asymmetry was observed in several PS, differing from previous research, potentially due to questionnaire use and disregard for clinical expertise.
  • This asymmetry can lead to a 'ceiling effect' and reduced likelihood ratios (LRs).
  • CBP correlates with 95% CIs, providing a measure of statistical certainty for PFR outcomes, which can be classified as 'Certain', 'Probable', 'Possible', or 'Questionable'.

Conclusions:

  • Asymmetry in PS frequency distributions can arise from practitioners not fully utilizing expert knowledge during symptom assessment.
  • A reliability classification based on CBP is more informative and better understood by homeopathic experts, though it remains partly subjective.
  • Corroboration of outcomes and clinical judgment are essential for determining the clinical validity of PFR findings; training in statistics and homeopathy is recommended for researchers and practitioners.