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Updated: Sep 20, 2025

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Steroids, peniciversiols and aspergilosidols from endophytic fungus Aspergillus sp. TZS-Y4
Yong-Fu Li1, Rui-Han Zhang2, Ling-Yan Liu2
1International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, GuangZhou 510632, PR China; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, HarBin Medical University, HarBin 150081, PR China.
Abstract:
Endophytic fungi have emerged as a crucial resource for medicinal drug development. The genus Aspergillus, in particular, has yielded diverse bioactive secondary metabolites. In this study, we isolated nine steroids, five peniciversiols, and two aspergilosidols from the endophytic fungus Aspergillus sp. TZS-Y4. Among these, six steroids-camphoratins K-O (1-6) and one aspergilosidol, eupenoxide B (15), were identified as novel compounds. Their structures were elucidated through comprehensive NMR spectroscopy, HR-MS/MS analysis, experimental ECD, and calculated ECD data. Anti-inflammatory activity was assessed via an LPS-induced NO release assay in RAW264.7 cells, with compound 5 showing significant inhibitory effects.
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