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Eosinophilic Myocarditis With Cerebral Infarction: The Etiology and Pathophysiology of Cerebral Thrombus

Daisuke Sato1, Takuya Kakutani2, Masashi Yamaguchi1

  • 1Department of Cardiology, Shonan Kamakura General Hospital, Kamakura, Japan.

JACC. Case Reports
|May 30, 2025
PubMed

Insights

Eosinophilic myocarditis (EM) can lead to rare cerebral infarctions, often caused by intraventricular thrombi. Histologic analysis of a cerebral thrombus confirmed this link, highlighting the need for vigilant monitoring in EM patients.

Area of Science:

  • Cardiology
  • Neurology
  • Pathology

Background:

  • Eosinophilic myocarditis (EM) is an inflammatory heart condition.
  • Cerebral infarction is a rare but severe complication of EM.
  • The precise mechanism linking EM to cerebral infarction requires further elucidation.

Observation:

  • A case study of EM complicated by cerebral infarction is presented.
  • Histologic examination of a cerebral thrombus was performed.
  • The thrombus was identified as the cause of cerebral infarction.

Findings:

  • Intraventricular thrombus formation is the primary cause of cerebral infarction in EM.
  • Histologic findings confirmed the embolic origin of the cerebral infarction.

Implications:

  • Early detection and management of intraventricular thrombi are crucial in EM patients.
  • Close monitoring for thromboembolic events is recommended for individuals with EM.
  • This case underscores the importance of understanding the embolic potential in EM.

Keywords:
cerebral infarctioncerebral thrombuseosinophilic granulomatosis with polyangiitiseosinophilic myocarditis

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