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Preventive Healthcare Services01:30

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Primary Healthcare Services01:30

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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Updated: Sep 19, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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From precision interventions to precision health.

Nicholas J Schork1,2,3,4,5, Laura H Goetz6,7

  • 1The Translational Genomics Research Institute, a part of the City of Hope National Medical Center, Phoenix, AZ (NJS, LHG), USA. nschork@tgen.org.

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|May 30, 2025
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Summary
This summary is machine-generated.

Precision medicines offer tailored treatments, but their exact effects and benefits require better prediction. New clinical trial strategies collecting human data are needed to understand these advanced therapies.

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Area of Science:

  • Pharmacogenomics
  • Clinical Pharmacology
  • Translational Medicine

Background:

  • Precision medicines, tailored to individual profiles, are rapidly advancing.
  • Current preclinical and clinical trial methods struggle to predict intervention precision.
  • Understanding mechanisms of action (MOAs), clinical effects, and individual utility is challenging.

Purpose of the Study:

  • To highlight the need for improved strategies in precision medicine research.
  • To emphasize the necessity of collecting human data for better prediction.
  • To address the limitations in current preclinical and clinical trial designs.

Main Methods:

  • Review of current precision medicine development and evaluation strategies.
  • Identification of data gaps in understanding intervention impact.
  • Proposal for built-for-purpose clinical trials.

Main Results:

  • Current methods are insufficient for anticipating the precise MOAs, clinical effects, and utility of precision medicines.
  • Data on living human beings is crucial for accurate assessment.
  • Need for tailored clinical trials to gather specific data.

Conclusions:

  • Enhanced clinical trial designs are essential for advancing precision medicine.
  • Collecting comprehensive human data will improve the prediction of treatment efficacy and patient benefit.
  • Future research must focus on built-for-purpose trials to realize the full potential of precision medicine.