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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

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Related Experiment Video

Updated: May 8, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

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Inflammatory response after stroke-A clinical observation study.

Björn Röyter1, Nellie Andréasson2, Bianka Forgo3,4,5

  • 1Department of Obstetrics and Gynecology, Faculty of Medicine and Health, Örebro University, SE-701 82, Örebro, Sweden. bjorn.royter@oru.se.

BMC Neurology
|May 30, 2025
PubMed
Summary

Acute stroke can cause mild increases in body temperature, C-reactive protein (CRP), and white blood cell (WBC) counts. Significantly higher levels of these markers usually indicate a complication, aiding in diagnosis.

Keywords:
CRPInfectionStrokeTemperatureWBC

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Area of Science:

  • Neurology
  • Inflammation Research
  • Clinical Diagnostics

Background:

  • Elevated body temperature and inflammatory markers are common in acute stroke.
  • The cause of these elevations (stroke vs. complication) is unclear, potentially hindering infection diagnosis and treatment.

Purpose of the Study:

  • To investigate the dynamics of inflammatory parameters in complication-free acute stroke patients.
  • To differentiate between stroke-induced inflammation and inflammation from complications.

Main Methods:

  • Prospective cohort study of acute stroke patients within 48 hours of symptom onset.
  • Daily monitoring for complications, with daily measurements of body temperature and blood inflammatory markers (CRP, WBC) for up to 10 days.
  • Comparison of early measurements with values at 90-day follow-up.

Main Results:

  • 70 patients included; 51 were complication-free.
  • Body temperature, CRP, and WBC were significantly elevated in the early days post-stroke compared to 90-day follow-up.
  • Peak elevations: body temperature (37.1°C at 24-48h), WBC (8.1 × 10^9/L at 0-24h), CRP (7.0 mg/L at 120-144h).

Conclusions:

  • Acute stroke can lead to mild elevations in CRP, WBC, and body temperature.
  • Higher levels (CRP > 50 mg/L, WBC > 11 × 10^9/L, temp > 38°C) are rare (<2.5%) in complication-free patients and likely indicate a complication.