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Photocurable and 3D Printable Functional Polyesters to Engineer Elastomeric Scaffolds for Biomedical Applications.

Xiaochu Ding1,2, Narangerel Gantumur3,4, Bruce P Lee5

  • 1Health Research Institute, Michigan Technological University, H-STEM 238, 1400 Townsend Drive, Houghton, MI, 49931, USA.

Macromolecular Bioscience
|May 31, 2025
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Summary

New functional photo-polyesters create tunable, printable elastomeric scaffolds for biomedical uses. These materials offer dual crosslinking for enhanced properties and cell compatibility, advancing medical device engineering.

Keywords:
biocompatible and biodegradable polyesterselastomersphoto‐printingthiol‐yne click chemistrytissue scaffolds

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Elastomeric scaffolds are crucial for biomedical applications, requiring precise control over mechanical properties and degradation.
  • Existing materials often lack the ability to simultaneously tune multiple properties effectively.
  • Functional block copolyesters offer a promising route to engineer advanced scaffold materials.

Purpose of the Study:

  • To develop photocurable functional block copolyesters for creating advanced elastomeric scaffolds.
  • To investigate the role of dual crosslinking (chemical and crystal-domain) in tuning material properties.
  • To assess the printability and cytocompatibility of the developed elastomers for biomedical applications.

Main Methods:

  • Synthesis of functional block copolyesters with soft and stiff segments.
  • Crosslinking via thiol-yne click chemistry under UV light with a photo-initiator.
  • Characterization of mechanical properties, degradation rates, and scaffold architecture using digital light processing (DLP).
  • In vitro cell culture studies using human umbilical vein endothelial cells (HUVECs).

Main Results:

  • The functional prepolymer was successfully crosslinked into a robust elastomer using UV light and thiol-yne chemistry.
  • Dual crosslinking significantly enhanced the tunability of mechanical properties and degradation rates compared to chemical crosslinking alone.
  • The material demonstrated excellent photo-printability via DLP, enabling precise control over scaffold pore sizes.
  • Hydroxyl groups on the polymer backbone promoted favorable endothelial cell adhesion and growth.

Conclusions:

  • Photocurable functional block copolyesters provide a versatile platform for engineering advanced elastomeric scaffolds.
  • Dual crosslinking offers superior control over material properties for tailored biomedical applications.
  • The photo-printable nature and cell-friendly surface make these materials highly suitable for constructing complex medical devices.
  • These functional photo-polyesters hold significant potential for future bioengineering research and medical device development.