Evolutionary interplay between viruses and R-loops
Zsolt Karányi1,2, Zita Képes3, Zoltán Szabó4
1MTA-DE Momentum Genome Architecture and Recombination Research Group, Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, Hungary.
None:
Viruses frequently interact with host transcriptional and epigenetic regulatory networks. A commonly overlooked element of these interactions is the formation of R-loops, three-stranded nucleic acid structures comprising an RNA-DNA hybrid and a displaced single DNA strand. Accumulating evidence implicates R-loops in viral integration site preferences, the regulation of latent viral genomes, epigenetic silencing, and even the genesis of small interfering RNAs (siRNAs) that modulate mobile viral elements. This perspective presents the potential connections among viral genes, transposons, and R-loops; examines the roles of R-loops in viral pathogenesis, latency, and reactivation; explores how viruses harness or evade R-loop-associated responses; and highlights future research directions-from mapping R-loop hotspots to exploiting R-loop modulation for antiviral therapy.
More Related Videos
10:38Large-scale Production of Recombinant RNAs on a Circular Scaffold Using a Viroid-derived System in Escherichia coli
Published on: November 30, 2018
06:44Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection
Published on: January 26, 2019
Related Concept Videos
Viral Mutations
Size and Structure of Viral Genomes
Retrovirus Life Cycles
Viruses with RNA Genomes
Retroviruses
Viral Recombination
