Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mediating effect of self-compassion and supportive communication between critical thinking and emotional intelligence in Chinese male nursing students.

BMC medical education·2026
Same author

Theory-guided cation engineering overcome V-based polyanion cathode kinetic performance limitation.

Journal of colloid and interface science·2026
Same author

Efficient on-site detection of nitazenes in hair: Integrating MCX pipette-tip solid-phase extraction with miniaturized mass spectrometry.

Talanta·2026
Same author

User personas for exercise rehabilitation behaviors in older patients with stable chronic obstructive pulmonary disease: a qualitative study.

Frontiers in public health·2026
Same author

Increased serum phenylalanine and tyrosine concentration related to inflammation in patients with primary angiitis of the central nervous system.

Biochemistry and biophysics reports·2026
Same author

Prevalence and Predictors of Cancer-Related Fatigue in Breast Cancer-Related Lymphedema Patients: A Cross-Sectional Study.

Lymphatic research and biology·2026

Related Experiment Video

Updated: Sep 19, 2025

A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis
08:45

A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis

Published on: July 12, 2019

8.9K

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain

Shanshan Bai1,2,3, Xuan Lu1,2,3, Xu Yan1,2

  • 1Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, 999077, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|May 31, 2025
PubMed
Summary

Cranial bone transport (CBT) surgery improves neurological function and reduces brain injury in rats. This technique enhances lymphatic drainage, accelerates healing, and promotes bone regeneration after traumatic brain injury (TBI).

Keywords:
cranial bone transportcranioplastymeningeal lymphatic drainageneuro‐inflammationtraumatic brain injury

More Related Videos

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats
07:36

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

Published on: December 8, 2014

23.8K
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:36

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

508

Related Experiment Videos

Last Updated: Sep 19, 2025

A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis
08:45

A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis

Published on: July 12, 2019

8.9K
A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats
07:36

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

Published on: December 8, 2014

23.8K
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:36

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

508

Area of Science:

  • Neurosurgery
  • Regenerative Medicine
  • Neuroscience

Background:

  • Traumatic brain injury (TBI) presents significant mortality and morbidity challenges, particularly in young adults, with limited therapeutic options.
  • Cranial bone transport (CBT) is an established surgical technique for bone reconstruction, offering a less invasive approach to cranial defects.

Purpose of the Study:

  • To investigate the efficacy of CBT surgery in promoting cranial bone regeneration and neurological functional recovery in a TBI model.
  • To elucidate the mechanisms underlying CBT's therapeutic effects, including its impact on meningeal lymphatic drainage and neuroinflammation.

Main Methods:

  • A TBI rat model was utilized to assess the effects of CBT surgery.
  • Neurological functions (learning, motor skills, memory) were evaluated post-treatment.
  • Meningeal lymphatic drainage was assessed using tracer uptake (OVA-A647).
  • Markers of neuroinflammation (Iba1) and tau pathology (P-tau) were analyzed.
  • The role of meningeal lymphatic vessels (MLVs) was investigated using VEGFR-3 inhibition (MAZ51).
  • Bone regeneration at CBT sites was examined post-surgery.

Main Results:

  • CBT treatment significantly reduced lesion size and improved learning, motor, and memory functions in TBI rats.
  • Enhanced meningeal lymphatic drainage was observed, with increased tracer uptake in MLVs and dCLNs.
  • CBT accelerated P-tau clearance and reduced Iba1-induced neuroinflammation.
  • Ablation of MLVs using MAZ51 abolished the therapeutic benefits of CBT.
  • CBT surgery promoted rapid bone regeneration and consolidation, replacing bone defects with new bone.

Conclusions:

  • Cranial bone transport surgery is a promising therapeutic strategy for improving neurological recovery and bone defect repair in TBI.
  • The beneficial effects of CBT are partly mediated by enhanced meningeal lymphatic drainage and modulation of neuroinflammation.
  • CBT facilitates both brain recovery and cranioplasty in TBI models, demonstrating its potential clinical utility.