Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Sep 19, 2025

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Published on: November 17, 2023

Ovariectomy/Orchidectomy in Rodents.

Antonia Sophocleous¹, Aymen I Idris²

¹Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus.

Methods in Molecular Biology (Clifton, N.J.)

|May 31, 2025

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Effect of Probiotics on the Management of Pain and Inflammation in Osteoarthritis: A Systematic Review and Meta-Analysis of Clinical Studies.

Nutrients·2024

Same author

Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation.

Scientific reports·2024

Same author

The Role of Nutrition in Osteoarthritis Development.

Nutrients·2023

Same author

TRAF6 as a potential target in advanced breast cancer: a systematic review, meta-analysis, and bioinformatics validation.

Scientific reports·2023

Same author

Effects of zoledronic acid on osteosarcoma progression and metastasis: systematic review and meta-analysis.

Clinical and experimental medicine·2022

Same author

Probiotics Inhibit Cartilage Damage and Progression of Osteoarthritis in Mice.

Calcified tissue international·2022

This chapter details ovariectomy and orchidectomy surgical techniques in rodents. It covers anesthesia, and pre-, peri-, and post-operative care for successful animal research.

Area of Science:

Veterinary Surgery
Rodent Models
Laboratory Animal Science

Background:

Ovariectomy and orchidectomy are common procedures in rodent research.
Standardized surgical protocols are essential for animal welfare and data integrity.

Purpose of the Study:

To provide a comprehensive guide to ovariectomy and orchidectomy in mice and rats.
To detail anesthesia, surgical techniques, and critical peri-operative care.

Main Methods:

Description of surgical procedures for ovariectomy (female rodents) and orchidectomy (male rodents).
Inclusion of anesthesia protocols and selection criteria.
Emphasis on pre-operative preparation, intra-operative monitoring, and post-operative management.

Keywords:

Androgen Bone loss Estrogen Mouse Orchidectomy Ovariectomy Rat Resorption Rodents Surgery

More Related Videos

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration

Published on: June 7, 2012

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

Related Experiment Videos

Last Updated: Sep 19, 2025

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Published on: November 17, 2023

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration

Published on: June 7, 2012

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

Main Results:

Detailed technical steps for performing ovariectomy and orchidectomy.
Guidance on appropriate anesthetic agents and supportive care.
Best practices for minimizing pain and ensuring recovery.

Conclusions:

This chapter serves as a valuable resource for researchers and technicians.
Proper execution of these procedures ensures animal welfare and reliable experimental outcomes.