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Related Experiment Video

Updated: Sep 19, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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White matter microstructural and cognitive function changes in bipolar depression patients with suicidal ideation.

Junfan Liang1, Rui Fan1, Xinyin Guo1

  • 1Department of Psychiatry, Fundamental and Clinical Research On Mental Disorders Key Laboratory of Luzhou, Laboratory of Neurological Diseases & Brain Function, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.

Brain Imaging and Behavior
|May 31, 2025
PubMed
Summary

This study found that reduced white matter integrity in the genu of the corpus callosum is linked to suicidal thoughts and cognitive deficits in bipolar depression patients. These findings highlight potential neuroanatomical markers for these debilitating symptoms.

Keywords:
Cognitive functionDiffusion tensor imagingSuicidal ideationbipolar depression

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Psychiatry

Background:

  • Bipolar depression is associated with suicidal ideation and cognitive impairment.
  • The underlying neuroanatomical mechanisms are not fully understood.

Purpose of the Study:

  • To investigate the neuroanatomical basis of suicidal ideation and cognitive dysfunction in bipolar depression using diffusion tensor imaging (DTI).
  • To identify differences in white matter integrity between patients with and without suicidal ideation and healthy controls.

Main Methods:

  • Diffusion tensor imaging (DTI) was performed on 40 patients with bipolar depression (20 with suicidal ideation, 20 without) and 20 healthy controls.
  • Tract-Based Spatial Statistics (TBSS) and covariance analysis were used to compare fractional anisotropy (FA) values.
  • Clinical assessments included the Beck Scale for Suicide Ideation (BSSI) and Trail Making Test (TMT).

Main Results:

  • Significantly lower FA values were observed in the genu of the corpus callosum and left anterior corona radiata in the suicidal ideation group compared to healthy controls.
  • FA values in the genu of the corpus callosum were negatively correlated with BSSI and TMT-A scores.

Conclusions:

  • Alterations in the connectivity of the genu of the corpus callosum may be associated with suicidal ideation and visuospatial function in bipolar depression.
  • DTI may help identify neuroanatomical correlates of severe symptoms in bipolar disorder.