Expanding the toolset of experimental Psychopathology: The Trier Social Stress Test induces a personally relevant...

Despite the remarkable progress in developing effective psychological interventions for emotional disorders, our understanding of the mechanisms driving therapeutic change remains strikingly limited. To bridge this gap, we need to refine experimental paradigms with high ecological validity and establish their clinical utility. In this study, we replicate and extend previous findings that the Trier Social Stress Test (TSST) can evoke persistent, sensory rich, and personally meaningful emotional memories. One week after the TSST, a student sample (N = 146) reported greater negative valence, arousal, and lack of control in response to TSST-related versus control cues. Participants reported intrusive memories, the content of which reflects the personal relevance, sensory richness, and emotionality of the TSST memory. Re-imagining the TSST through guided imagery evoked heightened emotional responses (skin conductance, heart rate, and self-report) and participants evaluated themselves more negatively due to the TSST. These effects correlated with trait anxiety. However, comparisons to a naïve sample that only experienced the TSST through guided imagery (N = 38) revealed that some findings, including changes in self-image, were not memory-induced. We conclude with concrete examples of how the paradigm can expand our toolset to further unravel mechanistic underpinnings of memory-focused interventions.