Covalent organic frameworks (COFs)-mediated multimodal sonodynamic therapy for the anticancer applications

Area of Science:

• Biomedical Engineering
• Materials Science
• Oncology

Background:

• Sonodynamic therapy (SDT) is an emerging anticancer treatment modality.
• Covalent organic frameworks (COFs) show promise in enhancing SDT efficacy.
• Nanodrugs based on COFs offer theranostic applications in cancer care.

Purpose of the Study:

• To provide a comprehensive review of COF-mediated SDT for cancer treatment.
• To systematically analyze the theranostic applications of COF-based nanodrugs.
• To elucidate the Type-I and Type-II activation mechanisms in COF-mediated SDT.

Main Methods:

• Review of literature on COF-based nanodrugs and SDT.
• Systematic analysis of COF-mediated SDT mechanisms (Type-I and Type-II).
• Examination of COF-coordinated multimodal SDT/X platforms.

Main Results:

• COFs significantly advance cancer treatment through SDT.
• COF-based nanodrugs demonstrate effective theranostic capabilities.
• Multimodal SDT/X platforms exhibit competitive superiority in anticancer applications.

Conclusions:

• COF-mediated SDT represents a significant advancement in nanomedicine for cancer therapy.
• Further development of COFs and SDT strategies will drive innovation in nanodrugs.
• Addressing challenges in COF-mediated SDT is crucial for future clinical translation.