Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

372
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
372
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

267
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
267
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

462
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
462
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

48
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
48
Nursing Assessment of the Genitourinary System III: Percussion and Auscultation01:22

Nursing Assessment of the Genitourinary System III: Percussion and Auscultation

124
The genitourinary system maintains the body's fluid balance, waste excretion, and overall homeostasis. Proper assessment is essential for early detection of disorders, with percussion and auscultation integral to this evaluation. These methods help identify signs of kidney or bladder issues and provide important diagnostic clues.Percussion for Kidney TendernessPercussion is used to assess tenderness and detect kidney and bladder abnormalities. A common method for determining kidney tenderness...
124
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

28
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
28

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Psychological factors as determinants of medical conditions, volume III.

Frontiers in psychology·2026
Same author

Left-sided mastectomy mimics LVEF decline on CZT-ERNA: a consideration for cardio-oncology practice.

Cardio-oncology (London, England)·2026
Same author

Sustained Improvement in Renal Function with Palopegteriparatide in Adults with Chronic Hypoparathyroidism: 2-Year Results from the Phase 3 PaTHway-Trial.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

A novel dynamic cardiac phantom for comparing blood pool and myocardial perfusion tracers: initial evaluation with CZT-ERNA and PET-MPI.

EJNMMI physics·2026
Same author

Cold Carbonated Water Reduces Interference from Extracardiac Gastric Activity During <sup>82</sup>Rb PET in Patients.

Journal of nuclear medicine technology·2026
Same author

Corticosteroid Exposure in Chronic Rhinosinusitis and Global Airway Disease: Adrenal and Bone Impact.

The Laryngoscope·2026

Related Experiment Video

Updated: Sep 19, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.3K

Assessing Chemotherapy-Induced Peripheral Neuropathy in Postmenopausal Breast Cancer Patients Using Vibration

August Nielsen1, Simone Diedrichsen Marstrand1, Djordje Marina1,2

  • 1Department of Nephrology and Endocrinology, Rigshospitalet, Copenhagen, Denmark.

Cancer Investigation
|May 31, 2025
PubMed
Summary

Chemotherapy-induced peripheral neuropathy (CIPN) in early breast cancer patients showed normalized vibration perception threshold (VPT) measurements after 3 years. However, subjective quality of life scores did not significantly improve, highlighting limitations in assessing CIPN.

Keywords:
Breast cancerChemotherapy-induced peripheral neuropathyEORTC QLQ-CIPN20Sensibility IndexVibration perception threshold

More Related Videos

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

9.4K
Whole Body Vibration Methods with Survivors of Polio
04:16

Whole Body Vibration Methods with Survivors of Polio

Published on: October 17, 2018

8.9K

Related Experiment Videos

Last Updated: Sep 19, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.3K
A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

9.4K
Whole Body Vibration Methods with Survivors of Polio
04:16

Whole Body Vibration Methods with Survivors of Polio

Published on: October 17, 2018

8.9K

Area of Science:

  • Oncology
  • Neuroscience
  • Clinical Trials

Background:

  • Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting side effect in early breast cancer (EBC) patients.
  • Understanding the long-term development and objective/subjective assessment of CIPN is crucial for patient management.

Purpose of the Study:

  • To investigate the 3-year development of CIPN in post-menopausal women with EBC.
  • To evaluate vibration perception threshold (VPT) measurements and the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (CIPN18) for CIPN assessment.

Main Methods:

  • Prospective study involving 90 EBC patients (50-70 years) and 30 healthy controls.
  • VPT measurements and CIPN18 questionnaires administered post-chemotherapy, and at 12 and 36-month follow-ups.
  • Statistical analyses included Spearman's rho and Generalized Additive Models.

Main Results:

  • VPT measurements were impaired post-chemotherapy but normalized by 36 months compared to controls.
  • Mean CIPN18 scores showed improvement, but it was not statistically significant.
  • Weak to moderate correlations were observed between VPT and CIPN18, with no significant correlation confirmed by advanced modeling.

Conclusions:

  • VPT measurements may normalize over 3 years in EBC patients, suggesting potential for spontaneous recovery.
  • Subjective quality of life scores (CIPN18) did not significantly improve, indicating a potential disconnect in patient-reported outcomes.
  • Limitations exist in correlating objective VPT measures with subjective CIPN18 scores, though VPT shows promise as an objective assessment tool.