Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Eyeball01:20

Anatomy of the Eyeball

6.2K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
6.2K
The Retina01:32

The Retina

67.9K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
67.9K
Vision01:24

Vision

53.0K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
53.0K
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

2.8K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
2.8K
Glaucoma: Overview01:25

Glaucoma: Overview

527
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
527
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

5.9K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vascular regeneration and blood flow recovery in glaucoma.

Frontiers in cell and developmental biology·2026
Same author

Reply.

Ophthalmology science·2026
Same author

Safety of insulin eye drops in the tratment of open angle glaucoma: a randomized phase I clinical trial.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same author

Blood flow patterns in mice are regulated by interpericyte tunneling nanotubes connecting functionally-opposite neuronal areas.

Nature communications·2026
Same author

Correction: Inhibitor of Apoptosis-Stimulating Protein of p53 (iASPP) Is Required for Neuronal Survival after Axonal Injury.

PloS one·2026
Same author

Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.

Investigative ophthalmology & visual science·2026
Same journal

Transcending Genome-Wide Association Studies to Create Useful Multi-omic Views of Glaucoma.

Progress in retinal and eye research·2026
Same journal

Cutting-edge cross-linking biomaterials advancing ophthalmic therapeutics.

Progress in retinal and eye research·2026
Same journal

Scleral remodeling in myopia: mechanisms and therapeutic approaches.

Progress in retinal and eye research·2026
Same journal

Macular fibrosis secondary to neovascular age-related macular degeneration: from clinic to biology.

Progress in retinal and eye research·2026
Same journal

Stromal Transplantation and corneal-sparing techniques in ectatic diseases.

Progress in retinal and eye research·2026
Same journal

Diabetic retinal disease cure accelerator: Modernizing staging and endpoints.

Progress in retinal and eye research·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2025

3D Visualization of Retinal Vascular Pericytes in Mice by Immunostaining
09:22

3D Visualization of Retinal Vascular Pericytes in Mice by Immunostaining

Published on: November 1, 2024

443

Pericytes in the optic nerve head.

Susannah Waxman1, Deborah Villafranca-Baughman2, Julie Phillippi3

  • 1Department of Ophthalmology, University of Pittsburgh, Pittsburgh PA, USA.

Progress in Retinal and Eye Research
|May 31, 2025
PubMed
Summary
This summary is machine-generated.

Pericytes, crucial for microvasculature, are found in the optic nerve head (ONH) and may play a role in glaucoma. Further research into ONH pericytes could lead to new glaucoma treatments.

Keywords:
Blood flowGlaucomaOptic nerve headPericyte

More Related Videos

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes
10:46

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Published on: October 7, 2018

10.0K
A High Output Method to Isolate Cerebral Pericytes from Mouse
06:49

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

8.4K

Related Experiment Videos

Last Updated: Jun 12, 2025

3D Visualization of Retinal Vascular Pericytes in Mice by Immunostaining
09:22

3D Visualization of Retinal Vascular Pericytes in Mice by Immunostaining

Published on: November 1, 2024

443
Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes
10:46

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Published on: October 7, 2018

10.0K
A High Output Method to Isolate Cerebral Pericytes from Mouse
06:49

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

8.4K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Cell Biology

Background:

  • Pericytes are contractile mural cells vital for microvasculature function, regulating blood flow and maintaining barriers.
  • Pericyte dysfunction is implicated in neurodegenerative diseases, but their role in the optic nerve head (ONH) in glaucoma is poorly understood.
  • The ONH is an early site of neurodegeneration in glaucoma, highlighting the need to study local pericyte contributions.

Purpose of the Study:

  • To summarize current knowledge on pericyte roles in ONH physiology and glaucoma.
  • To investigate the presence and potential function of pericytes in healthy and glaucomatous ONH.
  • To identify therapeutic targets for microvascular impairment in glaucoma.

Main Methods:

  • Literature review of pericyte functions in ONH health and glaucoma.
  • Histological examination of pericyte presence in mouse, nonhuman primate, and human ONH tissues.
  • Analysis of factors linking ONH dysfunction in glaucoma to pericyte dysfunction in other neurodegenerative conditions.

Main Results:

  • Pericytes were identified in the microvasculature of mouse, nonhuman primate, and human ONH.
  • Factors associated with ONH dysfunction in glaucoma showed links to pericyte dysfunction in other neurodegenerative diseases.
  • The presence of pericytes suggests a capacity for local function within the ONH.

Conclusions:

  • ONH pericytes are present across species, indicating their potential for local roles in microvascular regulation.
  • Pericytes represent a promising, yet understudied, target for addressing microvascular dysfunction in glaucoma.
  • Understanding pericyte contributions in health and disease is crucial for developing novel therapeutic strategies for glaucoma.