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Updated: Jan 18, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Anatomic Success of Treatment Modalities for Small Saphenous Vein Incompetence: A Systematic Review and Network
Sharon Oud1, Tamana Alozai2, Faridi S Jamaludin3
1Department of Surgery, Amsterdam University Medical Centres, Amsterdam, the Netherlands; Department of Surgery, Northwest Clinics, Alkmaar, the Netherlands.
Network meta-analysis shows radiofrequency ablation (RFA) and endovenous laser ablation (EVLA) are top treatments for small saphenous vein (SSV) issues. RFA excelled mid-term, while EVLA showed high success long-term.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Phlebology
Background:
- High-quality comparative studies on small saphenous vein (SSV) treatments are scarce.
- Evaluating different SSV treatment modalities is crucial for clinical decision-making.
Purpose of the Study:
- To conduct a network meta-analysis (NMA) and meta-analysis to compare anatomic success rates of various SSV treatments.
- To assess treatment efficacy at short, mid, and long-term follow-up intervals.
Main Methods:
- Systematic review of MEDLINE and Embase databases.
- Inclusion of cohort studies (prospective and retrospective) and randomized controlled trials (RCTs).
- Network meta-analysis for comparing multiple treatment modalities and meta-analysis for pooled results.
Main Results:
- Radiofrequency ablation (RFA) and endovenous laser ablation (EVLA) demonstrated the highest anatomic success rates.
- EVLA was ranked superior at short-term follow-up, and RFA at mid-term follow-up in the NMA.
- Meta-analysis reported highest success for RFA (98.4%) short-term, and EVLA (96.1% mid-term, 94.3% long-term).
Conclusions:
- Despite limitations in high-quality comparative studies, RFA and EVLA emerge as leading treatments for SSV.
- Further research with high-quality comparative studies is needed to definitively rank SSV treatments.
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