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Linking motor impulsivity to cue-induced craving and central beta oscillations in individuals with methamphetamine

Xiaohuanghao Yang1, Yun Zhao1, Jing Li1

  • 1School of Mental Health and Psychological Sciences, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province, PR China.

Behavioural Brain Research
|May 31, 2025
PubMed

Insights

Impulsivity in methamphetamine use disorder (MUD) is linked to craving via brain activity. Enhanced central beta oscillations may partially regulate this craving response in individuals with MUD.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Addiction Research

Background:

  • Methamphetamine use disorder (MUD) is associated with impulsivity and cue-induced craving.
  • Understanding the neurophysiological underpinnings of this relationship is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the neurophysiological mechanisms linking impulsivity and cue-induced craving in individuals with MUD.
  • To explore the role of central beta oscillations in modulating this association.

Main Methods:

  • Electroencephalography (EEG) recordings were obtained from males with MUD and healthy controls during rest and virtual reality cue exposure.
  • Mediation analysis was employed to examine the pathways between motor impulsivity, beta oscillations, and craving.

Main Results:

  • Central-parietal beta power (Cz/Cp1) significantly increased during cue exposure in MUD patients.
  • Motor impulsivity directly exacerbated craving and indirectly attenuated it via enhanced beta oscillations.
  • The net effect indicated incomplete compensation, with impulsivity still positively associated with craving.

Conclusions:

  • Central beta oscillations represent a potential neurophysiological biomarker for craving regulation in individuals with high impulsivity and MUD.
  • These findings offer insights into the complex interplay between impulsivity, brain activity, and craving in addiction.
Keywords:
BIS-11Beta oscillationsCravingImpulsivityMethamphetamine use disorderVAS

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