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Interaction between gut-heart axis in sepsis-induced cardiomyopathy
Zi-Kang Zhou1, Mu-Ming Yu1, Song-Tao Shou1
1Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
Pharmacological Research
|May 31, 2025
Summary
The gut microbiota impacts heart function in sepsis-induced cardiomyopathy (SIC). This review explores the bidirectional gut-heart axis and therapeutic strategies targeting this interaction.
Area of Science:
- Microbiology
- Cardiology
- Pathophysiology
Background:
- The gut microbiota and its metabolites significantly influence cardiac function.
- Sepsis-induced cardiomyopathy (SIC) involves complex gut-heart interactions.
- Therapeutic interventions for SIC can reciprocally affect gut microbial ecology.
Purpose of the Study:
- To systematically review the bidirectional relationship between the gut microbiota and the heart during SIC.
- To define and explore the 'forward gut-heart axis' (gut to heart).
- To define and explore the 'reverse gut-heart axis' (heart/drugs to gut).
Main Methods:
- Literature review focusing on the gut-heart axis in SIC.
- Analysis of studies investigating microbial metabolites and cardiac function.
- Examination of reciprocal effects of cardiac conditions and treatments on gut microbiota.
Main Results:
- The gut microbiota and its metabolites play a critical role in SIC pathophysiology.
- The 'forward gut-heart axis' describes gut-derived influences on cardiovascular health.
- The 'reverse gut-heart axis' details how cardiac factors and drugs impact the gut microbiome.
Conclusions:
- Understanding the bidirectional gut-heart axis is crucial for managing SIC.
- Targeting the gut-heart interplay offers novel therapeutic avenues for SIC.
- Modulating the gut microbiota presents a promising strategy for SIC treatment.
Keywords:
Gut microbiotaGut-Heart AxisLipopolysaccharideSepsis-Induced CardiomyopathyShort-chain Fatty AcidsMore Related Videos
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