Related Experiment Video

Updated: Sep 19, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

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Opportunities for the treatment of atherosclerosis: Selectins

Nong Li1, Chao Pi2, Siying Zhu2

  • 1Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou 646000, PR China; Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, PR China; Central Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR China.

Pharmacological Research
|May 31, 2025
PubMed

Insights

Selectins, often overlooked in atherosclerosis research, are now recognized for their therapeutic potential. Advances enable new diagnostic and treatment strategies for atherosclerosis targeting selectins.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomedical Engineering

Background:

  • Selectins' role in atherosclerosis has been historically underestimated due to technological constraints and their perceived cofactor status.
  • Recent advancements in immunohistology and glycomics necessitate a re-evaluation of selectin involvement in atherosclerosis pathogenesis.
  • This review bridges the gap between fundamental selectin mechanisms and their clinical applications in cardiovascular disease.

Purpose of the Study:

  • To reassess the significance of selectins in atherosclerosis.
  • To identify translational opportunities for selectin-based therapies.
  • To explore the clinical promise of selectins in atherosclerosis diagnosis and treatment.

Main Methods:

  • Comprehensive literature review of recent clinical research on selectins and atherosclerosis.
  • Analysis of selectin-specific tracers and inhibitors.
  • Exploration of technological advancements impacting selectin research.

Main Results:

  • Selectins play a more critical role in atherosclerosis than previously acknowledged.
  • Novel selectin-specific diagnostic tracers show promise for early detection.
  • Selectin inhibitors represent a potential therapeutic avenue for atherosclerosis.

Conclusions:

  • Selectins offer significant translational opportunities for atherosclerosis management.
  • Targeting selectins can lead to more precise diagnosis and treatment of atherosclerosis.
  • Further research into selectin-specific agents is warranted for clinical application.
Keywords:
AtherosclerosisSelectinsTranslational medicine

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