Related Experiment Video

Updated: Jun 30, 2026

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.8K

Lamina cribrosa perfusion density is reduced in eyes with central retinal vein occlusion

Matteo Menean1,2, Lorenzo Bianco3,4, Lida Perna3,4

  • 1School of Medicine, Vita-Salute San Raffaele University, Milan, Italy. menean.matteo@hsr.it.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|May 31, 2025
PubMed

Insights

Central retinal vein occlusion (CRVO) leads to decreased perfusion density in the lamina cribrosa. Structural changes in curvature suggest a stiffer microarchitecture, impacting blood flow in CRVO-affected eyes.

Area of Science:

  • Ophthalmology
  • Retinal Vascular Diseases
  • Ophthalmic Imaging

Background:

  • Central retinal vein occlusion (CRVO) is a significant cause of vision loss.
  • The precise etiology and pathophysiology of CRVO, particularly concerning the lamina cribrosa, remain incompletely understood.
  • Advanced imaging techniques are crucial for elucidating structural and vascular alterations in CRVO.

Purpose of the Study:

  • To investigate in-vivo structural and vascular changes of the lamina cribrosa in eyes affected by CRVO.
  • To compare these changes with healthy fellow eyes using Optical Coherence Tomography (OCT) and OCT-Angiography (OCTA).

Main Methods:

  • A retrospective, cross-sectional study involving 37 patients with CRVO and their healthy fellow eyes.
  • Quantification of lamina cribrosa thickness, curvature depth (CD), and curvature index (CI) using structural OCT.
  • Measurement of lamina cribrosa perfusion density (PD) via en-face OCTA.

Main Results:

  • No significant differences in lamina cribrosa thickness or depth were observed between CRVO and control eyes.
  • A trend towards higher curvature index (CI) and curvature depth (CD) in CRVO eyes.
  • Significantly decreased perfusion density (PD) in the lamina cribrosa of CRVO eyes compared to controls (p < 0.001).
  • PD showed no significant association with thickness, CD, CI, or intraocular pressure (IOP).

Conclusions:

  • In-vivo OCT and OCTA reveal distinct structural and vascular changes in the lamina cribrosa following CRVO onset.
  • Altered curvature in the lamina cribrosa may indicate a stiffer, more compressed microarchitecture.
  • These microarchitectural changes likely contribute to the observed reduction in intrinsic perfusion metrics in CRVO eyes.
Abstract

Keywords:
CRVOLamina cribrosaLamina cribrosa perfusion densityOCTOCT-A

More Related Videos

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

2.8K
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

1.9K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...