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The conduction system in patients with a prolonged QT interval.
Journal of the American College of Cardiology
|November 1, 1985
Summary
Romano-Ward and Jervell and Lange-Nielsen syndromes, characterized by prolonged QT intervals, showed common conduction system abnormalities, primarily fatty infiltration of the atrioventricular node, suggesting a link to repolarization disturbances.
Area of Science:
- Cardiology
- Pathology
- Genetics
Background:
- Romano-Ward syndrome and Jervell and Lange-Nielsen syndrome are inherited cardiac conditions associated with prolonged QT intervals.
- These syndromes increase the risk of life-threatening ventricular arrhythmias and sudden cardiac death.
- The precise pathological basis for the prolonged QT interval in these conditions remains incompletely understood.