Type 2 Diabetes Polygenic Risk Score Interactions with Lifestyle Risk Factors in Black Americans
Ashley W Scadden1, Aastha Kakar2, Elizabeth M Litkowski3
1Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA, ashley.scadden@cuanschutz.edu.
Introduction:
Prior work in predominantly European ancestry populations has explained how the risk associated with demographic, lifestyle, and health factors differs with underlying genetic susceptibility to type 2 diabetes (T2D), but less is known about these relationships in Black Americans.
Methods:
We used covariate-adjusted logistic regression models of T2D to examine interactions between a published trans-ancestry derived T2D polygenic risk score (PRS) and various demographic, lifestyle, and health-related factors among 28,251 self-identified Black Americans from six cohort studies.
Results:
The results are generally consistent with prior work in White populations. The PRS showed a significant interaction with body mass index, with a greater effect on T2D risk in individuals who were leaner (pinteraction = 0.038).
Conclusion:
These results contribute to understanding the relationship between genetics and other T2D risk factors in Black Americans who have a high burden of T2D, potentially informing targeted prevention strategies.
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