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Updated: Sep 19, 2025

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Type 2 Diabetes Polygenic Risk Score Interactions with Lifestyle Risk Factors in Black Americans.

Ashley W Scadden1, Aastha Kakar2, Elizabeth M Litkowski3

  • 1Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA, ashley.scadden@cuanschutz.edu.

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PubMed
Summary
This summary is machine-generated.

Type 2 diabetes (T2D) risk factors interact differently with genetic susceptibility in Black Americans. A polygenic risk score (PRS) showed greater T2D risk association in leaner individuals, informing targeted prevention.

Keywords:
Body mass indexDiabetesEpidemiologyLifestyle interactionsPolygenic risk scores

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Area of Science:

  • Genetics
  • Epidemiology
  • Public Health

Background:

  • Type 2 diabetes (T2D) risk factors and genetic susceptibility interactions are well-studied in European ancestry populations.
  • Limited research exists on these interactions within the Black American population, which faces a high burden of T2D.

Purpose of the Study:

  • To investigate how demographic, lifestyle, and health factors interact with genetic susceptibility to T2D in Black Americans.
  • To examine the role of a trans-ancestry polygenic risk score (PRS) in T2D risk within this population.

Main Methods:

  • Utilized covariate-adjusted logistic regression models.
  • Analyzed data from 28,251 self-identified Black Americans across six cohort studies.
  • Examined interactions between a T2D PRS and various risk factors.

Main Results:

  • Findings were generally consistent with previous studies in White populations.
  • A significant interaction was observed between the T2D PRS and body mass index (pinteraction = 0.038).
  • The PRS demonstrated a greater effect on T2D risk among leaner individuals.

Conclusions:

  • The study enhances understanding of genetic and non-genetic T2D risk factor interplay in Black Americans.
  • Results may inform the development of targeted prevention strategies for T2D in this high-risk group.