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Benchmarking test-retest variability in microperimetry for intermediate age-related macular degeneration using MP-3
Jakob Schweighofer1, Klaudia Birner2, Hamza Mohamed3
1Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Objective:
Microperimetry (MP) has emerged as a clinical functional endpoint in nonexudative age-related macular degeneration (AMD). In this study, we aim to provide reference values for test-retest outcomes on two MP devices in intermediate AMD (iAMD).
Design:
Prospective, cross-sectional study.
Participants:
3 600 stimuli from 20 eyes in 20 subjects.
Methods:
Patients diagnosed with iAMD underwent consecutive testing on MP-3 (NIKED, Gamagori, Japan) and MAIA (CenterVue Icare, Padova, Italy). The obtained point-wise sensitivity (PWS) measurements were superimposed with optical coherence tomography (OCT) (Spectralis, Heildelberg Engineering) acquired. Hyperreflective foci (HRF), drusen volume, ellipsoid zone (EZ)-thickness and outer nuclear layer (ONL)-thickness were quantified with deep-learning algorithms. Subretinal drusenoid deposits (SDD) were manually annotated. We assessed test-retest repeatability at the location of these biomarkers using Bland-Altmann coefficients of repeatability. Furthermore, interdevice correlation, fixation stabilities, and examination durations were evaluated.
Results:
Comparable overall point-wise retest variances were detected for MP-3 (±4.54 dB) and MAIA (±5.24 dB). SDDs led to significantly worse repeatability in the MAIA device (p = 0.03). Drusen, HRF, EZ-thickness, and ONL thickness had no significant impact on test-retest variance. A good intradevice correlation (MP-3: 0.869 [0.851 - 0.886] MAIA 0.848 [0.827 - 0.867]), and a good mean interdevice correlation (0.841 [0.819 - 0.861]) was observed.
Conclusions:
Intradevice and interdevice repeatability for MP examinations with MP-3 and MAIA in patients with iAMD can be considered as good. Biomarkers except for SDD show no significant impact in repeatability in both devices. This supports MP as a reliable functional endpoint in clinical trials in iAMD.
Insights
Microperimetry (MP) shows good test-retest reliability in intermediate age-related macular degeneration (iAMD). Devices MP-3 and MAIA demonstrate comparable outcomes, supporting MP
Area of Science:
- Ophthalmology
- Medical Technology
- Clinical Trials
Background:
- Microperimetry (MP) is a key functional endpoint for nonexudative age-related macular degeneration (AMD).
- Establishing reliable test-retest values is crucial for its clinical application in intermediate AMD (iAMD).
Purpose of the Study:
- To provide reference values for test-retest outcomes of two MP devices (MP-3 and MAIA) in patients with iAMD.
- To assess the impact of specific biomarkers on MP test-retest repeatability.
Main Methods:
- A prospective, cross-sectional study involving 20 subjects with iAMD.
- Consecutive testing on MP-3 and MAIA devices, with point-wise sensitivity (PWS) superimposed on OCT images.
- Analysis of biomarkers including hyperreflective foci (HRF), drusen, ellipsoid zone (EZ)-thickness, outer nuclear layer (ONL)-thickness, and subretinal drusenoid deposits (SDD).
Main Results:
- Both MP-3 and MAIA demonstrated comparable overall test-retest variances (±4.54 dB and ±5.24 dB, respectively).
- Subretinal drusenoid deposits (SDD) significantly impacted MAIA's repeatability (p=0.03).
- Good intradevice and interdevice correlations were observed for both devices.
Conclusions:
- Microperimetry (MP) exhibits good intradevice and interdevice repeatability in iAMD patients using MP-3 and MAIA devices.
- Biomarkers, excluding SDD, do not significantly affect test-retest repeatability.
- These findings support MP as a reliable functional endpoint in clinical trials for iAMD.
