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Related Concept Videos

Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

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Updated: Jun 19, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
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Echocardiographic parameters and risk factors for cardiomyopathy in Japanese childhood cancer survivors: A report

Naoko Ichikawa1, Daisuke Hasegawa2, Kyoko Nagase3

  • 1Clinical Laboratory, St. Luke's International Hospital, Tokyo, Japan.

Journal of Cardiology
|June 1, 2025
PubMed
Summary

Childhood cancer survivors (CCSs) face increased risks of cardiac dysfunction. A cumulative anthracycline dose over 150 mg/m² significantly elevates this risk, necessitating regular cardiac monitoring.

Keywords:
Cancer therapy-related cardiac dysfunctionCardio-oncologyChildhood cancer survivorsLeft ventricular systolic function

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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
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Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

Area of Science:

  • Cardiology
  • Oncology
  • Survivorship Research

Background:

  • Cardiac dysfunction is a serious long-term complication for childhood cancer survivors (CCSs).
  • Incidence of cardiac issues in CCSs is rising, underscoring the need for long-term follow-up.
  • Limited research exists on cardiac health in Japanese CCSs.

Purpose of the Study:

  • To investigate the prevalence and risk factors of cancer therapy-related cardiac dysfunction (CTRCD) in Japanese CCSs.
  • To identify specific thresholds for cardiotoxic therapies, like anthracyclines, associated with CTRCD.
  • To analyze cardiac function parameters in CCSs with and without CTRCD.

Main Methods:

  • Study included 108 CCSs (≥18 years old) and 26 siblings.
  • CCSs were categorized based on left ventricular ejection fraction (LVEF ≤53%) to define CTRCD.
  • Cardiac function, including left ventricular global longitudinal strain, was analyzed.
  • Receiver operating characteristic curve analysis determined the anthracycline dose threshold for CTRCD.

Main Results:

  • 14% (15/108) of CCSs developed CTRCD.
  • CTRCD group showed significantly reduced left ventricular global longitudinal strain.
  • A cumulative anthracycline dose exceeding 150 mg/m² was a significant risk factor for CTRCD (p<0.01).

Conclusions:

  • 14% of CCSs developed cardiomyopathy in young adulthood.
  • Regular cardiac follow-up is essential for CCSs.
  • CCSs receiving >150 mg/m² of anthracycline require particularly close monitoring for cardiotoxicity.