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Updated: Jun 12, 2025
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Preoperative Prediction Models for 30-Day All-Cause Mortality After Mitral Valve Repair in Dogs: A Single-Center
Shimon Furusato1,2, Kentaro Kurogochi1,3, Masashi Mizuno1
1JASMINE Veterinary Cardiovascular Medical Center, Yokohama, Japan.
Background:
Mitral valve repair (MVR) has emerged as a novel surgical intervention for dogs with myxomatous mitral valve disease (MMVD). However, no objective risk assessment method has been established for these cases.
Objectives:
The primary aim of this study was to develop and evaluate preoperative prediction models for 30-day postoperative mortality in dogs undergoing MVR. The secondary aim was to assess the association between short-term predictive risk and long-term mortality following MVR.
Animals:
A total of 2089 client-owned dogs with MMVD that underwent MVR between 2016 and 2023 were included.
Methods:
This was a single-center retrospective cohort study. Preoperative variables including demographic data, routine blood test results, diagnostic imaging examination data, and medication history were selected as predictor candidates. Prediction models for 30-day all-cause mortality were developed using these variables and shrinkage estimation methods, and the model performances were evaluated. The association between the predicted probabilities and 2-year cumulative all-cause mortality was assessed using Cox proportional hazards analysis.
Results:
The 30-day all-cause mortality rate after MVR was 4.9% (102/2089). The best preoperative prediction model for 30-day all-cause death demonstrated low-to-moderate discrimination abilities (c-statistics, 0.654) and good calibration performance (slope = 1.003; intercept = 0.007; Eavg = 0.002) in internal validation. The quartile grouping of the predicted 30-day all-cause mortality risk was associated with 2-year mortality.
Conclusions And Clinical Importance:
The preoperative prediction model for short-term mortality in dogs undergoing MVR demonstrated acceptable predictive performance. The prediction model may provide an objective preoperative risk assessment in dogs undergoing MVR at this center.
