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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Sep 19, 2025

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation

Published on: January 14, 2011

Efficient Artificial T Cell Therapy for Bacterial-Colonized Tumors.

Shiyu Zhang¹, Han Zhu¹, Xintao Peng¹

¹State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Centre for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, School of Medicine, and Frontiers Science Centre for Cell Responses, Nankai University, Tianjin, 300071, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)

|June 1, 2025

Summary

Artificial T cells (ATC) combat tumor-colonizing bacteria by delivering targeted antibacterial and antitumor agents. This innovative therapy enhances immune response and inhibits tumor spread, offering a new approach to precision medicine.

Keywords:

artificial T cells bacteriophage holin hydrogel microcapsules smart‐responsive tumor intracellular bacteria

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Related Experiment Videos

Last Updated: Sep 19, 2025

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation

Published on: January 14, 2011

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

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Published on: June 12, 2021

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

Area of Science:

Biotechnology
Immunology
Materials Science

Background:

Tumor-colonizing bacteria hinder cancer treatment efficacy and promote metastasis.
Cytotoxic T lymphocytes (CTLs) target tumor cells but cannot eliminate bacteria.

Purpose of the Study:

To develop artificial T cells (ATC) for treating tumors infected with intracellular bacteria.
To engineer a system for targeted delivery of antitumor and antibacterial agents.

Main Methods:

Constructed ATC using a hydrogel framework of disulfide-linked chitosan and hyaluronic acid.
Encapsulated T cell-derived granzyme B and phage-derived holin within the hydrogel.
Leveraged the tumor microenvironment for controlled release of therapeutic agents.

Main Results:

ATC effectively killed tumor cells and intracellular bacteria.
ATC-mediated destruction debris stimulated immune cell infiltration.
Demonstrated inhibition of tumor cell migration in vivo.
Showcased potential for robust anti-tumor immunity.

Conclusions:

ATC therapy offers a promising strategy for precision medicine against bacterial-infected tumors.
This approach advances artificial cell technology for enhanced cancer treatment.
ATC therapy can induce a potent anti-tumor immune response.