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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Related Experiment Video

Updated: Jan 18, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
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Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy.

Ahana Maitra1, Morena Miciaccia1, Manuela Mandorino1

  • 1Research, Laboratory for Woman and Child Health, Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Bari, Italy.

Medicinal Research Reviews
|June 2, 2025
PubMed
Summary

This review examines gene expression changes in pediatric brain tumors before and after radiotherapy. Understanding these molecular alterations can improve treatment strategies and patient survival for diffuse midline glioma.

Keywords:
cerebral tumoremerging and future therapeutic strategiesgene expression profileradiotherapy

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Area of Science:

  • Pediatric Oncology
  • Molecular Biology
  • Radiotherapy Research

Background:

  • Pediatric cerebral tumors present significant oncological challenges, with radiotherapy being a key treatment modality.
  • Understanding the molecular response to radiotherapy is vital for improving outcomes in pediatric cancer patients.
  • Limited research exists on gene expression changes post-radiotherapy in pediatric brain tumors, especially diffuse midline glioma.

Purpose of the Study:

  • To explore gene expression profiles in pediatric cerebral tumors before and after radiotherapy.
  • To elucidate molecular mechanisms driving treatment response and identify prognostic biomarkers.
  • To highlight potential therapeutic targets for personalized treatment strategies.

Main Methods:

  • Systematic review of scientific literature published between 2011 and 2023.
  • Analysis of gene expression patterns and signatures associated with radiotherapy response.
  • Focus on intrinsic brain tumors, particularly diffuse midline glioma.

Main Results:

  • Radiotherapy induces alterations in key signaling pathways, DNA repair mechanisms, and cell cycle regulation.
  • Identified potential genomic targets and critical genes/pathways involved in treatment response.
  • Highlighted the scarcity of studies on gene expression changes before and after radiotherapy in pediatric brain tumors.

Conclusions:

  • Gene expression profiling before and after radiotherapy offers insights into treatment response in pediatric cerebral tumors.
  • Identifying specific molecular alterations can guide the development of personalized therapeutic approaches.
  • Further research is needed to fully understand and leverage these molecular changes for improved patient survival and targeted therapies.