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Efficacy of Atorvastatin Against Venous Thromboembolism After Total Hip Arthroplasty

Huajiang Liu1, Yi Kang1

  • 1Orthopedics and Traumatology Department II, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, Nanchang, Jiangxi, China.

Journal of Musculoskeletal & Neuronal Interactions
|June 2, 2025
PubMed

Insights

Atorvastatin significantly reduced venous thromboembolism (VTE) and improved joint function after total hip arthroplasty (THA). This study highlights atorvastatin

Area of Science:

  • Orthopedic Surgery
  • Pharmacology
  • Vascular Medicine

Background:

  • Venous thromboembolism (VTE) is a significant complication following total hip arthroplasty (THA).
  • Effective VTE prophylaxis strategies are crucial for patient outcomes after THA.

Purpose of the Study:

  • To investigate the efficacy of atorvastatin in preventing and managing VTE after THA.
  • To assess the impact of atorvastatin on postoperative complications and functional recovery.

Main Methods:

  • A randomized controlled trial involving 300 patients undergoing THA.
  • The treatment group received 20 mg/day of oral atorvastatin post-surgery.
  • Outcomes measured included VTE incidence, bleeding, infection, pain, and joint function.

Main Results:

  • Atorvastatin significantly reduced the incidence of deep vein thrombosis and pulmonary embolism.
  • Lower rates of incision hemorrhage, infection, and ecchymosis were observed in the atorvastatin group.
  • Improved hemoglobin levels, reduced pain scores, and enhanced hip function were noted with atorvastatin treatment.

Conclusions:

  • Atorvastatin demonstrates significant efficacy in VTE prevention post-THA.
  • Atorvastatin improves postoperative joint function and reduces complications, making it a valuable therapeutic option.
Abstract

Keywords:
AtorvastatinTotal Hip ArthroplastyVenous Thromboembolism

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