Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

497
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
497
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

3.4K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
3.4K
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

1.4K
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
1.4K
Blind Procedures02:07

Blind Procedures

10.8K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.8K
Management of Insomnia01:19

Management of Insomnia

768
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
768

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.

Diabetes care·2026
Same author

Obesity Polygenic Risk and Healthy Lifestyle Interactions on Weight Trajectories in Women and Men.

Journal of the American Heart Association·2026
Same author

Genetic variants affect diurnal glucose levels throughout the day.

Nature communications·2026
Same author

Promise and Uncertainty of Intermittent Fasting for Aging Populations.

Advances in nutrition (Bethesda, Md.)·2026
Same author

Objective prediction of siesta based on machine learning and association with obesity.

Sleep health·2026
Same author

Associations of continuous glucose monitor derived time in range and glycaemic variability with diet lifestyle and demographics.

Nature communications·2026

Related Experiment Video

Updated: Apr 28, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

10.8K

Daytime Napping in Adults: Benefits or Risks? Insights from Mendelian Randomization Studies.

Aarohi Gupta1, Hassan S Dashti1,2,3

  • 1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Current Sleep Medicine Reports
|June 2, 2025
PubMed
Summary
This summary is machine-generated.

Daytime napping frequency shows mixed health effects. Mendelian randomization studies found no definitive link, with some suggesting increased disease risk and others no association.

Keywords:
Daytime NappingGenome-wide Association StudiesHealth OutcomesMendelian Randomization

More Related Videos

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

9.6K
Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.9K

Related Experiment Videos

Last Updated: Apr 28, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

10.8K
Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

9.6K
Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.9K

Area of Science:

  • Genetics and Epidemiology
  • Sleep Science
  • Public Health

Background:

  • Daytime napping, a brief sleep episode, has uncertain health implications.
  • Traditional epidemiological studies often face confounding and reverse causality issues.
  • Mendelian randomization (MR) offers a method to address these limitations.

Purpose of the Study:

  • To review Mendelian randomization (MR) studies investigating the association between daytime napping frequency and various health outcomes.
  • To synthesize evidence on the causal relationship between napping and disease risk, mitigating confounding factors.

Main Methods:

  • Systematic review and synthesis of published Mendelian randomization (MR) studies.
  • Analysis included studies examining cardiovascular, neurological, metabolic, and other health outcomes.
  • Focused on studies that utilized genetic variants to infer causal relationships.

Main Results:

  • 35 MR studies covering seven major disease categories were analyzed.
  • 36% of tested outcomes suggested increased disease risk with frequent daytime napping.
  • 54% reported no association, and 10% suggested decreased risk; findings varied and did not always align with observational data.

Conclusions:

  • Current Mendelian randomization evidence does not establish a definitive conclusion on the health effects of daytime napping frequency.
  • Further research is needed, exploring napping dimensions beyond frequency and incorporating diverse populations and methodologies.
  • Integrating genetic and non-genetic approaches will provide a more comprehensive understanding.