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Inhaled Triple Therapy with Extrafine Single Inhaler Versus Multiple Devices in Chronic Obstructive Pulmonary Disease
Eva Cabrera César1, Javier López García1, Daniel Enrique Vega Lizarazo1
1Pulmonology Department, Virgen de la Victoria University Hospital, Málaga, Spain.
Summary
Switching to extrafine single inhaler triple therapy (efSITT) for chronic obstructive pulmonary disease (COPD) significantly reduced exacerbations and improved adherence compared to multiple inhaler triple therapy (MITT). This real-world study highlights efSITT
Area of Science:
- Pulmonology
- Pharmacology
- Clinical Medicine
Background:
- Triple therapy is crucial for uncontrolled chronic obstructive pulmonary disease (COPD) but often involves multiple inhalers, potentially impacting patient adherence.
- Real-world evidence comparing extrafine single inhaler triple therapy (efSITT) with multiple inhalers triple therapy (MITT) for moderate-to-severe COPD is limited.
Purpose of the Study:
- To compare the effectiveness of efSITT versus MITT in patients with moderate-to-severe COPD.
- To evaluate the impact on exacerbations, rescue medication use, adherence, and lung function in a real-world setting.
Main Methods:
- The TRIPOLI study was a unicentric retrospective observational study.
- It compared one year of efSITT (beclomethasone dipropionate, formoterol fumarate dihydrate, glycopyrronium) with one year of MITT in 71 COPD patients.
Main Results:
- efSITT significantly reduced total exacerbations by 27.56% and moderate exacerbations by 29.56%.
- Patient adherence improved significantly with efSITT, decreasing poor adherence from 30.2% to 9.9% and increasing complete adherence from 55.8% to 81.7%.
- Mean forced expiratory volume in the first second (% pred) improved by 2.29% with efSITT; no difference in pneumonia rates was observed.
Conclusions:
- Switching from MITT to efSITT may reduce exacerbations in moderate-to-severe COPD patients.
- Improved adherence in real-world settings is a likely factor contributing to the observed benefits of efSITT.
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