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Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

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Related Experiment Video

Updated: May 12, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

Interobserver Variability in Cardiovascular FDG PET/CT Analysis in Large Vessel Vasculitis.

Redemptar Kimeu1, Anoop Shah2, Samuel Gitau3

  • 1The Nairobi Hospital, Nairobi, KE.

Global Heart
|June 2, 2025
PubMed
Summary
This summary is machine-generated.

This study found excellent agreement between observers for measuring 18F-FDG uptake in the aorta of patients with COVID-19 large vessel vasculitis using PET/CT scans. Both visual and quantitative standardized uptake value (SUV) measurements were highly reproducible.

Keywords:
FGD/CT PETLarge vessel vasculitisVasculitisinterobserver variabilitystandardized uptake values

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Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images
08:02

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

Area of Science:

  • Cardiovascular Imaging
  • Nuclear Medicine
  • Rheumatology

Background:

  • Positron Emission Tomography/Computed Tomography (PET/CT) is valuable for diagnosing and monitoring large vessel vasculitis.
  • Standardized uptake values (SUV) are used to quantify tissue uptake in PET/CT, but their reproducibility in vascular structures needs further study.
  • COVID-19 infection can be associated with large vessel vasculitis, necessitating reliable imaging assessment.

Purpose of the Study:

  • To evaluate the inter-observer variability of qualitative visual grading and quantitative standardized uptake values (SUVmean and SUVmax) of aortic 18F-FDG uptake.
  • To assess the reproducibility of these measurements in patients with COVID-19 related large vessel vasculitis.

Main Methods:

  • A sub-study of the COSMIC-19 trial involving 30 patients with mild to moderate COVID-19.
  • Combined Computed Tomography Coronary Angiogram and 18F-FDG PET/CT followed by cardiac magnetic resonance.
  • Two independent observers measured SUVmean and SUVmax in five regions of interest along the aorta on axial slices.

Main Results:

  • Excellent inter-observer agreement was observed for qualitative visual grading of aortic 18F-FDG uptake (kappa coefficients > 0.90).
  • High positive correlations were found between observers for quantitative SUVmean measurements in the ascending aorta (r=0.96), aortic arch (r=0.90), and descending aorta (r=0.91).
  • Quantitative SUVmax measurements also demonstrated substantially strong inter-observer reproducibility.

Conclusions:

  • There is excellent inter-observer reproducibility for both qualitative and quantitative 18F-FDG measurements of aortic uptake in patients with COVID-19 related large vessel vasculitis.
  • Standardized uptake value (SUV) measurements, particularly SUVmean, are reliable for assessing vascular inflammation in this patient group.
  • The findings support the use of PET/CT with SUV measurements for monitoring disease activity and progression in large vessel vasculitis associated with COVID-19.